MEI1 Chromosome 22
Meiotic double-stranded break formation protein 1
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What This Gene Does
Predicted to be involved in meiosis I. Predicted to act upstream of or within germ cell development; meiotic nuclear division; and meiotic spindle organization. Implicated in gestational trophoblastic neoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Gene Info
Gene Group
Armadillo like helical domain containing
Locus Type
gene with protein product
Location
22q13.2
Ensembl
ENSG00000167077
Associated Conditions (4)
Hydatidiform mole
recurrent
3
MEI1-related disorder
Key Variants
RS1043792591
Likely pathogenic
Health Risk
RS199977360
Likely pathogenic
Health Risk
RS375815319
Likely pathogenic
Health Risk
RS749779829
Likely pathogenic
Hydatidiform mole, recurrent, 3
Health Risk
RS75338000
Likely pathogenic
Hydatidiform mole, recurrent, 3
Health Risk
RS1569203272
Pathogenic
Hydatidiform mole, recurrent, 3
Health Risk
RS2518836614
Pathogenic
Health Risk
RS759915989
Pathogenic
Hydatidiform mole, recurrent, 3
Health Risk
All Variants (8)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1043792591 | Health Risk | Likely pathogenic | — |
| RS199977360 | Health Risk | Likely pathogenic | — |
| RS375815319 | Health Risk | Likely pathogenic | — |
| RS749779829 | Health Risk | Likely pathogenic | Hydatidiform mole, recurrent, 3 |
| RS75338000 | Health Risk | Likely pathogenic | Hydatidiform mole, recurrent, 3 |
| RS1569203272 | Health Risk | Pathogenic | Hydatidiform mole, recurrent, 3 |
| RS2518836614 | Health Risk | Pathogenic | — |
| RS759915989 | Health Risk | Pathogenic | Hydatidiform mole, recurrent, 3 |