MAP3K6 Chromosome 1

Mitogen-activated protein kinase kinase kinase 6

1 variant 1 Health Risk

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What This Gene Does

This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Gene Info

Gene Group

Mitogen-activated protein kinase kinase kinases

Locus Type

gene with protein product

Location

1p36.11

Ensembl

ENSG00000142733

Key Variants

RS34008139

Likely pathogenic

Health Risk

All Variants (1)

RSID	Category	Clinical Significance	Conditions
RS34008139	Health Risk	Likely pathogenic	—