MAOA Chromosome X
Monoamine oxidase A
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What This Gene Does
This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]
Gene Info
Gene Group
Flavoproteins
Locus Type
gene with protein product
Location
Xp11.3
Ensembl
ENSG00000189221
Associated Conditions (8)
Brunner syndrome
Inborn genetic diseases
See cases
Intellectual disability
Autism
severe
Antisocial behavior
susceptibility to
Key Variants
RS138703731
Conflicting classifications of pathogenicity
Brunner syndrome, Inborn genetic diseases, Brunner syndrome
Health Risk
RS142659522
Conflicting classifications of pathogenicity
Inborn genetic diseases, Brunner syndrome, Inborn genetic diseases
Health Risk
RS144688481
Conflicting classifications of pathogenicity
See cases, Inborn genetic diseases, Brunner syndrome
Health Risk
RS1800466
Conflicting classifications of pathogenicity
Brunner syndrome, Inborn genetic diseases, Brunner syndrome
Health Risk
RS2147103024
Conflicting classifications of pathogenicity
Brunner syndrome, Inborn genetic diseases, Brunner syndrome
Health Risk
RS574432879
Conflicting classifications of pathogenicity
Brunner syndrome, Inborn genetic diseases, Brunner syndrome
Health Risk
RS772161607
Conflicting classifications of pathogenicity
Inborn genetic diseases, Brunner syndrome, Inborn genetic diseases
Health Risk
RS777420059
Conflicting classifications of pathogenicity
Intellectual disability, Inborn genetic diseases, Brunner syndrome
Health Risk
RS780043965
Conflicting classifications of pathogenicity
Inborn genetic diseases, Brunner syndrome, Inborn genetic diseases
Health Risk
RS1135401773
Likely pathogenic
Brunner syndrome, Brunner syndrome
Health Risk
RS2033551253
Likely pathogenic
Brunner syndrome, Brunner syndrome
Health Risk
RS2519124859
Likely pathogenic
Health Risk
All Variants (20)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS138703731 | Health Risk | Conflicting classifications of pathogenicity | Brunner syndrome, Inborn genetic diseases, Brunner syndrome |
| RS142659522 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Brunner syndrome, Inborn genetic diseases |
| RS144688481 | Health Risk | Conflicting classifications of pathogenicity | See cases, Inborn genetic diseases, Brunner syndrome |
| RS1800466 | Health Risk | Conflicting classifications of pathogenicity | Brunner syndrome, Inborn genetic diseases, Brunner syndrome |
| RS2147103024 | Health Risk | Conflicting classifications of pathogenicity | Brunner syndrome, Inborn genetic diseases, Brunner syndrome |
| RS574432879 | Health Risk | Conflicting classifications of pathogenicity | Brunner syndrome, Inborn genetic diseases, Brunner syndrome |
| RS772161607 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Brunner syndrome, Inborn genetic diseases |
| RS777420059 | Health Risk | Conflicting classifications of pathogenicity | Intellectual disability, Inborn genetic diseases, Brunner syndrome |
| RS780043965 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Brunner syndrome, Inborn genetic diseases |
| RS1135401773 | Health Risk | Likely pathogenic | Brunner syndrome, Brunner syndrome |
| RS2033551253 | Health Risk | Likely pathogenic | Brunner syndrome, Brunner syndrome |
| RS2519124859 | Health Risk | Likely pathogenic | — |
| RS1555951288 | Health Risk | Pathogenic | — |
| RS2147107556 | Health Risk | Pathogenic | Brunner syndrome, Brunner syndrome |
| RS2519132239 | Health Risk | Pathogenic | Brunner syndrome, Brunner syndrome |
| RS587777457 | Health Risk | Pathogenic | Brunner syndrome, Brunner syndrome |
| RS72554632 | Health Risk | Pathogenic | Brunner syndrome, Brunner syndrome |
| RS796065311 | Health Risk | Pathogenic | Brunner syndrome, Brunner syndrome |
| RS1346551029 | Health Risk | Pathogenic; risk factor | Autism, severe, Antisocial behavior |
| RS796065312 | Health Risk | Pathogenic/Likely pathogenic | Brunner syndrome, Brunner syndrome |