LRRK2 Chromosome 12
Leucine rich repeat kinase 2
Upload your DNA to see your personal genotypes for variants in LRRK2.
What This Gene Does
This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
"ROCO family|Armadillo like helical domain containing|Leucine rich repeat kinase family"
Locus Type
gene with protein product
Location
12q12
Ensembl
ENSG00000188906
Associated Conditions (16)
Autosomal dominant Parkinson disease 8
Inborn genetic diseases
Sarcoma
Parkinson disease
Acute myeloid leukemia
Early onset Alzheimer disease with behavioral disturbance
Spinocerebellar atrophy
Klippel-Feil syndrome 1
autosomal dominant
LRRK2-related disorder
late-onset
Interstitial pulmonary disease
Young-onset Parkinson disease
Leprosy
susceptibility to
1
Key Variants
RS111691891
Conflicting classifications of pathogenicity
Autosomal dominant Parkinson disease 8, Autosomal dominant Parkinson disease 8
Health Risk
RS112794616
Conflicting classifications of pathogenicity
Autosomal dominant Parkinson disease 8, Autosomal dominant Parkinson disease 8
Health Risk
RS113511708
Conflicting classifications of pathogenicity
Autosomal dominant Parkinson disease 8, Autosomal dominant Parkinson disease 8
Health Risk
RS11564176
Conflicting classifications of pathogenicity
Autosomal dominant Parkinson disease 8, Autosomal dominant Parkinson disease 8
Health Risk
RS1179163564
Conflicting classifications of pathogenicity
Autosomal dominant Parkinson disease 8, Inborn genetic diseases, Autosomal dominant Parkinson disease 8
Health Risk
RS138264225
Conflicting classifications of pathogenicity
Autosomal dominant Parkinson disease 8, Inborn genetic diseases, Autosomal dominant Parkinson disease 8
Health Risk
RS139746572
Conflicting classifications of pathogenicity
Autosomal dominant Parkinson disease 8, Inborn genetic diseases, Autosomal dominant Parkinson disease 8
Health Risk
RS141221000
Conflicting classifications of pathogenicity
Autosomal dominant Parkinson disease 8, Sarcoma, Autosomal dominant Parkinson disease 8
Health Risk
RS141262110
Conflicting classifications of pathogenicity
Autosomal dominant Parkinson disease 8, Inborn genetic diseases, Autosomal dominant Parkinson disease 8
Health Risk
RS1422910994
Conflicting classifications of pathogenicity
Autosomal dominant Parkinson disease 8, Autosomal dominant Parkinson disease 8
Health Risk
RS148143226
Conflicting classifications of pathogenicity
Autosomal dominant Parkinson disease 8, Inborn genetic diseases, Autosomal dominant Parkinson disease 8
Health Risk
RS150422099
Conflicting classifications of pathogenicity
Autosomal dominant Parkinson disease 8, Autosomal dominant Parkinson disease 8
Health Risk
All Variants (65)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS111691891 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Autosomal dominant Parkinson disease 8 |
| RS112794616 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Autosomal dominant Parkinson disease 8 |
| RS113511708 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Autosomal dominant Parkinson disease 8 |
| RS11564176 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Autosomal dominant Parkinson disease 8 |
| RS1179163564 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Inborn genetic diseases, Autosomal dominant Parkinson disease 8 |
| RS138264225 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Inborn genetic diseases, Autosomal dominant Parkinson disease 8 |
| RS139746572 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Inborn genetic diseases, Autosomal dominant Parkinson disease 8 |
| RS141221000 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Sarcoma, Autosomal dominant Parkinson disease 8 |
| RS141262110 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Inborn genetic diseases, Autosomal dominant Parkinson disease 8 |
| RS1422910994 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Autosomal dominant Parkinson disease 8 |
| RS148143226 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Inborn genetic diseases, Autosomal dominant Parkinson disease 8 |
| RS150422099 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Autosomal dominant Parkinson disease 8 |
| RS17466213 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Autosomal dominant Parkinson disease 8 |
| RS182233369 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Inborn genetic diseases, Autosomal dominant Parkinson disease 8 |
| RS1942177952 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Inborn genetic diseases, Autosomal dominant Parkinson disease 8 |
| RS1944946235 | Health Risk | Conflicting classifications of pathogenicity | Parkinson disease, Parkinson disease |
| RS199854074 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Inborn genetic diseases, Autosomal dominant Parkinson disease 8 |
| RS199964631 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Inborn genetic diseases, Autosomal dominant Parkinson disease 8 |
| RS200002022 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Autosomal dominant Parkinson disease 8 |
| RS200143418 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Autosomal dominant Parkinson disease 8 |
| RS200437744 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Autosomal dominant Parkinson disease 8 |
| RS200795955 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Autosomal dominant Parkinson disease 8 |
| RS201184634 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Autosomal dominant Parkinson disease 8 |
| RS201389324 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Autosomal dominant Parkinson disease 8 |
| RS201559861 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Acute myeloid leukemia, Autosomal dominant Parkinson disease 8 |
| RS202179802 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Autosomal dominant Parkinson disease 8 |
| RS33949390 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Early onset Alzheimer disease with behavioral disturbance, Spinocerebellar atrophy |
| RS33995463 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Autosomal dominant Parkinson disease 8 |
| RS35173587 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Autosomal dominant Parkinson disease 8 |
| RS35328937 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Autosomal dominant Parkinson disease 8 |
| RS35517158 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Inborn genetic diseases, Autosomal dominant Parkinson disease 8 |
| RS35602796 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Autosomal dominant Parkinson disease 8 |
| RS35658131 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Autosomal dominant Parkinson disease 8 |
| RS372245035 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Inborn genetic diseases, LRRK2-related disorder |
| RS376621322 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Inborn genetic diseases |
| RS41286476 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Autosomal dominant Parkinson disease 8 |
| RS41286480 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Autosomal dominant Parkinson disease 8 |
| RS568593066 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Autosomal dominant Parkinson disease 8, Inborn genetic diseases |
| RS58559150 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Autosomal dominant Parkinson disease 8 |
| RS60185966 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Autosomal dominant Parkinson disease 8 |
| RS72546315 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Inborn genetic diseases, LRRK2-related disorder |
| RS72546338 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Autosomal dominant Parkinson disease 8 |
| RS7308720 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Autosomal dominant Parkinson disease 8 |
| RS748213808 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Autosomal dominant Parkinson disease 8 |
| RS754436306 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Autosomal dominant Parkinson disease 8 |
| RS756480297 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Autosomal dominant Parkinson disease 8 |
| RS757454147 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Inborn genetic diseases, Autosomal dominant Parkinson disease 8 |
| RS761017682 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Autosomal dominant Parkinson disease 8, Inborn genetic diseases |
| RS77018758 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Autosomal dominant Parkinson disease 8 |
| RS773085638 | Health Risk | Conflicting classifications of pathogenicity | Autosomal dominant Parkinson disease 8, Inborn genetic diseases, Autosomal dominant Parkinson disease 8 |