LRRC56 Chromosome 11
Leucine rich repeat containing 56
Upload your DNA to see your personal genotypes for variants in LRRC56.
What This Gene Does
Predicted to be involved in cell projection organization. Predicted to be located in cilium. Implicated in primary ciliary dyskinesia 39. [provided by Alliance of Genome Resources, Jul 2025]
Gene Info
Gene Group
Axonemal dynein assembly factors
Locus Type
gene with protein product
Location
11p15.5
Ensembl
ENSG00000161328
Associated Conditions (5)
LRRC56-related disorder
Ciliary dyskinesia
primary
39
Kartagener syndrome
Key Variants
RS113808353
Conflicting classifications of pathogenicity
Health Risk
RS138766042
Conflicting classifications of pathogenicity
LRRC56-related disorder, LRRC56-related disorder
Health Risk
RS149919024
Conflicting classifications of pathogenicity
Ciliary dyskinesia, primary, 39
Health Risk
RS1852307190
Conflicting classifications of pathogenicity
Ciliary dyskinesia, primary, 39
Health Risk
RS372006680
Conflicting classifications of pathogenicity
Health Risk
RS752363538
Conflicting classifications of pathogenicity
Health Risk
RS752922900
Conflicting classifications of pathogenicity
LRRC56-related disorder, LRRC56-related disorder
Health Risk
RS772525350
Conflicting classifications of pathogenicity
Health Risk
RS1331420078
Likely pathogenic
Health Risk
RS2539909801
Likely pathogenic
Health Risk
RS2539928316
Likely pathogenic
Health Risk
RS1221197180
Pathogenic
Health Risk
All Variants (23)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS113808353 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS138766042 | Health Risk | Conflicting classifications of pathogenicity | LRRC56-related disorder, LRRC56-related disorder |
| RS149919024 | Health Risk | Conflicting classifications of pathogenicity | Ciliary dyskinesia, primary, 39 |
| RS1852307190 | Health Risk | Conflicting classifications of pathogenicity | Ciliary dyskinesia, primary, 39 |
| RS372006680 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS752363538 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS752922900 | Health Risk | Conflicting classifications of pathogenicity | LRRC56-related disorder, LRRC56-related disorder |
| RS772525350 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS1331420078 | Health Risk | Likely pathogenic | — |
| RS2539909801 | Health Risk | Likely pathogenic | — |
| RS2539928316 | Health Risk | Likely pathogenic | — |
| RS1221197180 | Health Risk | Pathogenic | — |
| RS138918564 | Health Risk | Pathogenic | LRRC56-related disorder, LRRC56-related disorder |
| RS1564800859 | Health Risk | Pathogenic | Ciliary dyskinesia, primary, 39 |
| RS1564805039 | Health Risk | Pathogenic | Ciliary dyskinesia, primary, 39 |
| RS1564805053 | Health Risk | Pathogenic | Ciliary dyskinesia, primary, 39 |
| RS2539921362 | Health Risk | Pathogenic | — |
| RS2539932445 | Health Risk | Pathogenic | — |
| RS2539933089 | Health Risk | Pathogenic | — |
| RS372959912 | Health Risk | Pathogenic | Ciliary dyskinesia, primary, 39 |
| RS761092893 | Health Risk | Pathogenic | — |
| RS1421592107 | Health Risk | Pathogenic/Likely pathogenic | Kartagener syndrome, Kartagener syndrome |
| RS2539848777 | Health Risk | Pathogenic/Likely pathogenic | Ciliary dyskinesia, primary, 39 |