LGR4 Chromosome 11
Leucine rich repeat containing G protein-coupled receptor 4
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What This Gene Does
The protein encoded by this gene is a G-protein coupled receptor that binds R-spondins and activates the Wnt signaling pathway. This Wnt signaling pathway activation is necessary for proper development of many organs of the body. [provided by RefSeq, Oct 2016]
Gene Info
Gene Group
G protein-coupled receptors, Class A orphans
Locus Type
gene with protein product
Location
11p14.1
Ensembl
ENSG00000205213
Associated Conditions (3)
Bone mineral density quantitative trait locus 17
Delayed puberty
self-limited
Key Variants
All Variants (3)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS587777005 | Health Risk | association | Bone mineral density quantitative trait locus 17, Bone mineral density quantitative trait locus 17 |
| RS34804482 | Health Risk | Pathogenic | Delayed puberty, self-limited, Delayed puberty |
| RS757351670 | Health Risk | Pathogenic | Delayed puberty, self-limited, Delayed puberty |