KSR2 Chromosome 12
Kinase suppressor of ras 2
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What This Gene Does
Enables protein serine/threonine kinase activity. Predicted to be involved in Ras protein signal transduction; calcium-mediated signaling; and positive regulation of cold-induced thermogenesis. Predicted to act upstream of or within positive regulation of MAPK cascade. Predicted to be located in membrane. Predicted to be active in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Gene Info
Gene Group
RAF family
Locus Type
gene with protein product
Location
12q24.22-q24.23
Ensembl
ENSG00000171435
Associated Conditions (1)
KSR2-related disorder
Key Variants
All Variants (2)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS2542037480 | Health Risk | Likely pathogenic | KSR2-related disorder, KSR2-related disorder |
| RS2542061584 | Health Risk | Likely pathogenic | KSR2-related disorder, KSR2-related disorder |