KLRB1 Chromosome 12
Killer cell lectin like receptor B1
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What This Gene Does
Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
"CD molecules|Killer cell lectin like receptors|C-type lectin domain containing"
Locus Type
gene with protein product
Location
12p13.31
Ensembl
ENSG00000111796
All Variants (1)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS779033858 | Health Risk | Conflicting classifications of pathogenicity | — |