KIF11 Chromosome 10

Kinesin family member 11

168 variants 168 Health Risk

Upload your DNA to see your personal genotypes for variants in KIF11.

What This Gene Does

This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. [provided by RefSeq, Jul 2008]

Gene Info

Gene Group

Kinesins

Locus Type

gene with protein product

Location

10q23.33

Ensembl

ENSG00000138160

Associated Conditions (20)

Microcephaly with or without chorioretinopathy

lymphedema

or intellectual disability

Inborn genetic diseases

Exudative vitreoretinopathy 1

CTCF-related neurodevelopmental disorder

Optic atrophy

Retinal dystrophy

Hereditary ataxia

Retinal dysplasia

Microcephaly

Lymphedema

Neurodevelopmental disorder

KIF11-related disorder

Malignant tumor of urinary bladder

Retinitis pigmentosa

Microcephaly and chorioretinopathy 1

lymphedema or intellectual disability (MCLID)

Syndromic retinitis pigmentosa

Neurodevelopmental delay

Key Variants

RS1235363221

Conflicting classifications of pathogenicity

Microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability

Health Risk

RS1249211050

Conflicting classifications of pathogenicity

Inborn genetic diseases, Inborn genetic diseases

Health Risk

RS140534766

Conflicting classifications of pathogenicity

Health Risk

RS1554861545

Conflicting classifications of pathogenicity

Microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability

Health Risk

RS1564704121

Conflicting classifications of pathogenicity

Health Risk

RS1589597598

Conflicting classifications of pathogenicity

Health Risk

RS1844616530

Conflicting classifications of pathogenicity

Microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability

Health Risk

RS1844763810

Conflicting classifications of pathogenicity

Health Risk

RS189734472

Conflicting classifications of pathogenicity

Health Risk

RS200410468

Conflicting classifications of pathogenicity

Microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability

Health Risk

RS201865099

Conflicting classifications of pathogenicity

Hereditary ataxia, Hereditary ataxia

Health Risk

RS374124829

Conflicting classifications of pathogenicity

Inborn genetic diseases, Inborn genetic diseases

Health Risk

All Variants (168)

RSID	Category	Clinical Significance	Conditions
RS1235363221	Health Risk	Conflicting classifications of pathogenicity	Microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability
RS1249211050	Health Risk	Conflicting classifications of pathogenicity	Inborn genetic diseases, Inborn genetic diseases
RS140534766	Health Risk	Conflicting classifications of pathogenicity	—
RS1554861545	Health Risk	Conflicting classifications of pathogenicity	Microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability
RS1564704121	Health Risk	Conflicting classifications of pathogenicity	—
RS1589597598	Health Risk	Conflicting classifications of pathogenicity	CTCF-related neurodevelopmental disorder, CTCF-related neurodevelopmental disorder
RS1844616530	Health Risk	Conflicting classifications of pathogenicity	Microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability
RS1844763810	Health Risk	Conflicting classifications of pathogenicity	—
RS189734472	Health Risk	Conflicting classifications of pathogenicity	—
RS200410468	Health Risk	Conflicting classifications of pathogenicity	Microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability
RS201865099	Health Risk	Conflicting classifications of pathogenicity	Hereditary ataxia, Hereditary ataxia
RS374124829	Health Risk	Conflicting classifications of pathogenicity	Inborn genetic diseases, Inborn genetic diseases
RS387906642	Health Risk	Conflicting classifications of pathogenicity	Microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability
RS387906643	Health Risk	Conflicting classifications of pathogenicity	Microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability
RS547554309	Health Risk	Conflicting classifications of pathogenicity	Inborn genetic diseases, Inborn genetic diseases
RS746977730	Health Risk	Conflicting classifications of pathogenicity	Microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability
RS750912244	Health Risk	Conflicting classifications of pathogenicity	—
RS751639011	Health Risk	Conflicting classifications of pathogenicity	Inborn genetic diseases, Inborn genetic diseases
RS752393043	Health Risk	Conflicting classifications of pathogenicity	Microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability
RS756180389	Health Risk	Conflicting classifications of pathogenicity	Inborn genetic diseases, Inborn genetic diseases
RS756984680	Health Risk	Conflicting classifications of pathogenicity	—
RS757088457	Health Risk	Conflicting classifications of pathogenicity	—
RS758761887	Health Risk	Conflicting classifications of pathogenicity	Inborn genetic diseases, Inborn genetic diseases
RS766343259	Health Risk	Conflicting classifications of pathogenicity	Inborn genetic diseases, Inborn genetic diseases
RS776614086	Health Risk	Conflicting classifications of pathogenicity	Inborn genetic diseases, Inborn genetic diseases
RS779361129	Health Risk	Conflicting classifications of pathogenicity	Inborn genetic diseases, Inborn genetic diseases
RS781259791	Health Risk	Conflicting classifications of pathogenicity	Microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability
RS781705800	Health Risk	Conflicting classifications of pathogenicity	Inborn genetic diseases, Inborn genetic diseases
RS1057518980	Health Risk	Likely pathogenic	Retinal dysplasia, Microcephaly, Lymphedema
RS1057519141	Health Risk	Likely pathogenic	—
RS1064795570	Health Risk	Likely pathogenic	—
RS1554859399	Health Risk	Likely pathogenic	—
RS1554860819	Health Risk	Likely pathogenic	—
RS1554862197	Health Risk	Likely pathogenic	Microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability
RS1554863016	Health Risk	Likely pathogenic	Microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability
RS1554863182	Health Risk	Likely pathogenic	—
RS1554863246	Health Risk	Likely pathogenic	Microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability
RS1564713037	Health Risk	Likely pathogenic	Microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability
RS1589600695	Health Risk	Likely pathogenic	Microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability
RS1844462612	Health Risk	Likely pathogenic	Microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability
RS1844517913	Health Risk	Likely pathogenic	Microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability
RS1844615558	Health Risk	Likely pathogenic	Retinal dystrophy, Retinal dystrophy
RS1844750166	Health Risk	Likely pathogenic	Microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability
RS1844944116	Health Risk	Likely pathogenic	Retinal dystrophy, Retinal dystrophy
RS2135901156	Health Risk	Likely pathogenic	Microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability
RS2135902435	Health Risk	Likely pathogenic	Microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability
RS2135904871	Health Risk	Likely pathogenic	Microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability
RS2135904903	Health Risk	Likely pathogenic	Neurodevelopmental disorder, Neurodevelopmental disorder
RS2135904919	Health Risk	Likely pathogenic	Microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability
RS2135920462	Health Risk	Likely pathogenic	—

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