KHK Chromosome 2

Ketohexokinase
3 variants 3 Health Risk

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What This Gene Does
This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Associated Conditions (1)
Essential fructosuria
Key Variants
All Variants (3)
RSID Category Clinical Significance Conditions
RS114353144 Health Risk Conflicting classifications of pathogenicity Essential fructosuria, Essential fructosuria
RS780961189 Health Risk Conflicting classifications of pathogenicity Essential fructosuria, Essential fructosuria
RS104893644 Health Risk Pathogenic Essential fructosuria, Essential fructosuria
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