KCNMA1 Chromosome 10
Potassium calcium-activated channel subfamily M alpha 1
Upload your DNA to see your personal genotypes for variants in KCNMA1.
What This Gene Does
This gene encodes the alpha subunit of calcium-activated BK channel. The encoded protein is involved in several physiological processes including smooth muscle contraction, neurotransmitter release and neuronal excitability. Mutations in this gene are associated with a spectrum of neurological disorders including Paroxysmal Nonkinesigenic Dyskinesia 3, Idiopathic Generalized Epilepsy 16 and Liang-Wang syndrome. [provided by RefSeq, Aug 2022]
Gene Info
Gene Group
Potassium calcium-activated channels
Locus Type
gene with protein product
Location
10q22.3
Ensembl
ENSG00000156113
Associated Conditions (14)
Generalized epilepsy-paroxysmal dyskinesia syndrome
KCNMA1-related disorder
Cerebellar atrophy
developmental delay
and seizures
Epilepsy
idiopathic generalized
susceptibility to
16
Liang-Wang syndrome
Inborn genetic diseases
Infantile epileptic dyskinetic encephalopathy
Intellectual disability
Autism spectrum disorder
Key Variants
RS1043608536
Conflicting classifications of pathogenicity
Generalized epilepsy-paroxysmal dyskinesia syndrome, Generalized epilepsy-paroxysmal dyskinesia syndrome
Health Risk
RS115273369
Conflicting classifications of pathogenicity
Generalized epilepsy-paroxysmal dyskinesia syndrome, KCNMA1-related disorder, Generalized epilepsy-paroxysmal dyskinesia syndrome
Health Risk
RS1350886458
Conflicting classifications of pathogenicity
Generalized epilepsy-paroxysmal dyskinesia syndrome, Generalized epilepsy-paroxysmal dyskinesia syndrome
Health Risk
RS139309224
Conflicting classifications of pathogenicity
Generalized epilepsy-paroxysmal dyskinesia syndrome, Generalized epilepsy-paroxysmal dyskinesia syndrome
Health Risk
RS142210216
Conflicting classifications of pathogenicity
Generalized epilepsy-paroxysmal dyskinesia syndrome, Generalized epilepsy-paroxysmal dyskinesia syndrome
Health Risk
RS143562140
Conflicting classifications of pathogenicity
Generalized epilepsy-paroxysmal dyskinesia syndrome, KCNMA1-related disorder, Generalized epilepsy-paroxysmal dyskinesia syndrome
Health Risk
RS143599540
Conflicting classifications of pathogenicity
Generalized epilepsy-paroxysmal dyskinesia syndrome, Generalized epilepsy-paroxysmal dyskinesia syndrome
Health Risk
RS144215383
Conflicting classifications of pathogenicity
Generalized epilepsy-paroxysmal dyskinesia syndrome, KCNMA1-related disorder, Generalized epilepsy-paroxysmal dyskinesia syndrome
Health Risk
RS1445232499
Conflicting classifications of pathogenicity
Generalized epilepsy-paroxysmal dyskinesia syndrome, Generalized epilepsy-paroxysmal dyskinesia syndrome
Health Risk
RS145048715
Conflicting classifications of pathogenicity
Generalized epilepsy-paroxysmal dyskinesia syndrome, Generalized epilepsy-paroxysmal dyskinesia syndrome
Health Risk
RS147369374
Conflicting classifications of pathogenicity
Generalized epilepsy-paroxysmal dyskinesia syndrome, Generalized epilepsy-paroxysmal dyskinesia syndrome
Health Risk
RS147378590
Conflicting classifications of pathogenicity
Generalized epilepsy-paroxysmal dyskinesia syndrome, KCNMA1-related disorder, Generalized epilepsy-paroxysmal dyskinesia syndrome
Health Risk
All Variants (112)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1043608536 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS115273369 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, KCNMA1-related disorder, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS1350886458 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS139309224 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS142210216 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS143562140 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, KCNMA1-related disorder, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS143599540 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS144215383 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, KCNMA1-related disorder, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS1445232499 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS145048715 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS147369374 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS147378590 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, KCNMA1-related disorder, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS1484259264 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, Cerebellar atrophy, developmental delay |
| RS149647577 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, KCNMA1-related disorder, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS1554841751 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS1564596167 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS1591664697 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS188354139 | Health Risk | Conflicting classifications of pathogenicity | Cerebellar atrophy, developmental delay, and seizures |
| RS199572145 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS199818612 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS200045097 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS200166976 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS200167721 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS200196183 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, Liang-Wang syndrome, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS200321180 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS200440843 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, Inborn genetic diseases, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS200474297 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS200714367 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS200741233 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS201397661 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS201919794 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS201924445 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, KCNMA1-related disorder, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS201999021 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS202124080 | Health Risk | Conflicting classifications of pathogenicity | Epilepsy, idiopathic generalized, susceptibility to |
| RS202161397 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, KCNMA1-related disorder, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS2092522027 | Health Risk | Conflicting classifications of pathogenicity | Liang-Wang syndrome, Liang-Wang syndrome |
| RS2093898757 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, Inborn genetic diseases, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS2096371289 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, Inborn genetic diseases, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS2229008 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, KCNMA1-related disorder, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS2551803002 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, Liang-Wang syndrome, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS367642241 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS368568833 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS370838557 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS370862113 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS373648078 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS373677230 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, Cerebellar atrophy, developmental delay |
| RS377596790 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, KCNMA1-related disorder, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS41281550 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS549360933 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, Generalized epilepsy-paroxysmal dyskinesia syndrome |
| RS558650814 | Health Risk | Conflicting classifications of pathogenicity | Generalized epilepsy-paroxysmal dyskinesia syndrome, Liang-Wang syndrome, Cerebellar atrophy |