IL36RN Chromosome 2
Interleukin 36 receptor antagonist
Upload your DNA to see your personal genotypes for variants in IL36RN.
What This Gene Does
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
Interleukins
Locus Type
gene with protein product
Location
2q14.1
Ensembl
ENSG00000136695
Associated Conditions (6)
Generalized pustular psoriasis
Acrodermatitis continua suppurativa of Hallopeau
Inborn genetic diseases
Autoinflammatory syndrome
IL36RN-related disorder
Deficiency of the interleukin-36 receptor antagonist
Key Variants
RS139497891
Conflicting classifications of pathogenicity
Generalized pustular psoriasis, Acrodermatitis continua suppurativa of Hallopeau, Generalized pustular psoriasis
Health Risk
RS1424377493
Conflicting classifications of pathogenicity
Generalized pustular psoriasis, Inborn genetic diseases, Generalized pustular psoriasis
Health Risk
RS144182857
Conflicting classifications of pathogenicity
Generalized pustular psoriasis, Autoinflammatory syndrome, Generalized pustular psoriasis
Health Risk
RS151274071
Conflicting classifications of pathogenicity
Generalized pustular psoriasis, Autoinflammatory syndrome, IL36RN-related disorder
Health Risk
RS1800930
Conflicting classifications of pathogenicity
Generalized pustular psoriasis, Acrodermatitis continua suppurativa of Hallopeau, Generalized pustular psoriasis
Health Risk
RS199824136
Conflicting classifications of pathogenicity
Generalized pustular psoriasis, Generalized pustular psoriasis
Health Risk
RS202059991
Conflicting classifications of pathogenicity
Generalized pustular psoriasis, Deficiency of the interleukin-36 receptor antagonist, Generalized pustular psoriasis
Health Risk
RS2472188
Conflicting classifications of pathogenicity
Generalized pustular psoriasis, Acrodermatitis continua suppurativa of Hallopeau, Generalized pustular psoriasis
Health Risk
RS2515401
Conflicting classifications of pathogenicity
Generalized pustular psoriasis, Acrodermatitis continua suppurativa of Hallopeau, Generalized pustular psoriasis
Health Risk
RS2515402
Conflicting classifications of pathogenicity
Generalized pustular psoriasis, Acrodermatitis continua suppurativa of Hallopeau, Generalized pustular psoriasis
Health Risk
RS28938771
Conflicting classifications of pathogenicity
Generalized pustular psoriasis, Autoinflammatory syndrome, Generalized pustular psoriasis
Health Risk
RS28938778
Conflicting classifications of pathogenicity
Generalized pustular psoriasis, Autoinflammatory syndrome, Generalized pustular psoriasis
Health Risk
All Variants (27)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS139497891 | Health Risk | Conflicting classifications of pathogenicity | Generalized pustular psoriasis, Acrodermatitis continua suppurativa of Hallopeau, Generalized pustular psoriasis |
| RS1424377493 | Health Risk | Conflicting classifications of pathogenicity | Generalized pustular psoriasis, Inborn genetic diseases, Generalized pustular psoriasis |
| RS144182857 | Health Risk | Conflicting classifications of pathogenicity | Generalized pustular psoriasis, Autoinflammatory syndrome, Generalized pustular psoriasis |
| RS151274071 | Health Risk | Conflicting classifications of pathogenicity | Generalized pustular psoriasis, Autoinflammatory syndrome, IL36RN-related disorder |
| RS1800930 | Health Risk | Conflicting classifications of pathogenicity | Generalized pustular psoriasis, Acrodermatitis continua suppurativa of Hallopeau, Generalized pustular psoriasis |
| RS199824136 | Health Risk | Conflicting classifications of pathogenicity | Generalized pustular psoriasis, Generalized pustular psoriasis |
| RS202059991 | Health Risk | Conflicting classifications of pathogenicity | Generalized pustular psoriasis, Deficiency of the interleukin-36 receptor antagonist, Generalized pustular psoriasis |
| RS2472188 | Health Risk | Conflicting classifications of pathogenicity | Generalized pustular psoriasis, Acrodermatitis continua suppurativa of Hallopeau, Generalized pustular psoriasis |
| RS2515401 | Health Risk | Conflicting classifications of pathogenicity | Generalized pustular psoriasis, Acrodermatitis continua suppurativa of Hallopeau, Generalized pustular psoriasis |
| RS2515402 | Health Risk | Conflicting classifications of pathogenicity | Generalized pustular psoriasis, Acrodermatitis continua suppurativa of Hallopeau, Generalized pustular psoriasis |
| RS28938771 | Health Risk | Conflicting classifications of pathogenicity | Generalized pustular psoriasis, Autoinflammatory syndrome, Generalized pustular psoriasis |
| RS28938778 | Health Risk | Conflicting classifications of pathogenicity | Generalized pustular psoriasis, Autoinflammatory syndrome, Generalized pustular psoriasis |
| RS3180234 | Health Risk | Conflicting classifications of pathogenicity | Generalized pustular psoriasis, Acrodermatitis continua suppurativa of Hallopeau, Generalized pustular psoriasis |
| RS3180235 | Health Risk | Conflicting classifications of pathogenicity | Generalized pustular psoriasis, Acrodermatitis continua suppurativa of Hallopeau, Generalized pustular psoriasis |
| RS374849220 | Health Risk | Conflicting classifications of pathogenicity | Generalized pustular psoriasis, Autoinflammatory syndrome, Generalized pustular psoriasis |
| RS397514630 | Health Risk | Conflicting classifications of pathogenicity | Generalized pustular psoriasis, Acrodermatitis continua suppurativa of Hallopeau, Generalized pustular psoriasis |
| RS760489144 | Health Risk | Conflicting classifications of pathogenicity | Generalized pustular psoriasis, Autoinflammatory syndrome, Generalized pustular psoriasis |
| RS77864207 | Health Risk | Conflicting classifications of pathogenicity | Generalized pustular psoriasis, Autoinflammatory syndrome, Generalized pustular psoriasis |
| RS144478519 | Health Risk | Likely pathogenic | Generalized pustular psoriasis, Autoinflammatory syndrome, Acrodermatitis continua suppurativa of Hallopeau |
| RS1489262806 | Health Risk | Likely pathogenic | Generalized pustular psoriasis, Generalized pustular psoriasis |
| RS1685627126 | Health Risk | Likely pathogenic | Generalized pustular psoriasis, Generalized pustular psoriasis |
| RS2466802788 | Health Risk | Likely pathogenic | Generalized pustular psoriasis, Generalized pustular psoriasis |
| RS2466805738 | Health Risk | Pathogenic | Generalized pustular psoriasis, Generalized pustular psoriasis |
| RS387906914 | Health Risk | Pathogenic | Generalized pustular psoriasis, Acrodermatitis continua suppurativa of Hallopeau, Generalized pustular psoriasis |
| RS397514629 | Health Risk | Pathogenic | Acrodermatitis continua suppurativa of Hallopeau, Acrodermatitis continua suppurativa of Hallopeau |
| RS747464195 | Health Risk | Pathogenic | Generalized pustular psoriasis, Generalized pustular psoriasis |
| RS148755083 | Health Risk | Pathogenic/Likely pathogenic | Generalized pustular psoriasis, Autoinflammatory syndrome, Acrodermatitis continua suppurativa of Hallopeau |