IL31RA Chromosome 5
Interleukin 31 receptor A
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What This Gene Does
The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
Gene Info
Gene Group
"Fibronectin type III domain containing|Interleukin receptors"
Locus Type
gene with protein product
Location
5q11.2
Ensembl
ENSG00000164509
Associated Conditions (4)
IL31RA-related disorder
Amyloidosis
primary localized cutaneous
2
Key Variants
All Variants (2)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS144829917 | Health Risk | Conflicting classifications of pathogenicity | IL31RA-related disorder, IL31RA-related disorder |
| RS1561123748 | Health Risk | Pathogenic | Amyloidosis, primary localized cutaneous, 2 |