IL10RB Chromosome 21
Interleukin 10 receptor subunit beta
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What This Gene Does
The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
"CD molecules|Interleukin receptors"
Locus Type
gene with protein product
Location
21q22.11
Ensembl
ENSG00000243646
Associated Conditions (5)
Inflammatory bowel disease 25
IL10RB-related disorder
Hepatitis B virus
susceptibility to
Inborn genetic diseases
Key Variants
RS1058861
Conflicting classifications of pathogenicity
Inflammatory bowel disease 25, IL10RB-related disorder, Inflammatory bowel disease 25
Health Risk
RS112943706
Conflicting classifications of pathogenicity
Inflammatory bowel disease 25, Hepatitis B virus, susceptibility to
Health Risk
RS141414815
Conflicting classifications of pathogenicity
Inflammatory bowel disease 25, Inborn genetic diseases, Inflammatory bowel disease 25
Health Risk
RS148466782
Conflicting classifications of pathogenicity
Inflammatory bowel disease 25, Inflammatory bowel disease 25
Health Risk
RS148468217
Conflicting classifications of pathogenicity
Inflammatory bowel disease 25, Inflammatory bowel disease 25
Health Risk
RS182875134
Conflicting classifications of pathogenicity
Inflammatory bowel disease 25, IL10RB-related disorder, Inflammatory bowel disease 25
Health Risk
RS200472684
Conflicting classifications of pathogenicity
Inflammatory bowel disease 25, Inflammatory bowel disease 25
Health Risk
RS370841672
Conflicting classifications of pathogenicity
Inflammatory bowel disease 25, Inborn genetic diseases, Inflammatory bowel disease 25
Health Risk
RS374161818
Conflicting classifications of pathogenicity
Inflammatory bowel disease 25, Inflammatory bowel disease 25
Health Risk
RS376143910
Conflicting classifications of pathogenicity
Inflammatory bowel disease 25, Inborn genetic diseases, Inflammatory bowel disease 25
Health Risk
RS45526732
Conflicting classifications of pathogenicity
Inflammatory bowel disease 25, Inflammatory bowel disease 25
Health Risk
RS45545138
Conflicting classifications of pathogenicity
Inflammatory bowel disease 25, IL10RB-related disorder, Inflammatory bowel disease 25
Health Risk
All Variants (28)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1058861 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 25, IL10RB-related disorder, Inflammatory bowel disease 25 |
| RS112943706 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 25, Hepatitis B virus, susceptibility to |
| RS141414815 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 25, Inborn genetic diseases, Inflammatory bowel disease 25 |
| RS148466782 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 25, Inflammatory bowel disease 25 |
| RS148468217 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 25, Inflammatory bowel disease 25 |
| RS182875134 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 25, IL10RB-related disorder, Inflammatory bowel disease 25 |
| RS200472684 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 25, Inflammatory bowel disease 25 |
| RS370841672 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 25, Inborn genetic diseases, Inflammatory bowel disease 25 |
| RS374161818 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 25, Inflammatory bowel disease 25 |
| RS376143910 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 25, Inborn genetic diseases, Inflammatory bowel disease 25 |
| RS45526732 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 25, Inflammatory bowel disease 25 |
| RS45545138 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 25, IL10RB-related disorder, Inflammatory bowel disease 25 |
| RS531765635 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 25, Inflammatory bowel disease 25 |
| RS765506701 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 25, Inborn genetic diseases, Inflammatory bowel disease 25 |
| RS777216483 | Health Risk | Conflicting classifications of pathogenicity | Inflammatory bowel disease 25, Inborn genetic diseases, Inflammatory bowel disease 25 |
| RS1989175848 | Health Risk | Likely pathogenic | Inflammatory bowel disease 25, Inflammatory bowel disease 25 |
| RS1989179205 | Health Risk | Likely pathogenic | Inflammatory bowel disease 25, Inflammatory bowel disease 25 |
| RS2123556583 | Health Risk | Likely pathogenic | Inflammatory bowel disease 25, Inflammatory bowel disease 25 |
| RS2516776217 | Health Risk | Likely pathogenic | Inflammatory bowel disease 25, Inflammatory bowel disease 25 |
| RS778708008 | Health Risk | Likely pathogenic | — |
| RS121909601 | Health Risk | Pathogenic | Inflammatory bowel disease 25, Inflammatory bowel disease 25 |
| RS1373354533 | Health Risk | Pathogenic | Inflammatory bowel disease 25, Inflammatory bowel disease 25 |
| RS1989014468 | Health Risk | Pathogenic | Inflammatory bowel disease 25, Inflammatory bowel disease 25 |
| RS2516790668 | Health Risk | Pathogenic | Inflammatory bowel disease 25, Inflammatory bowel disease 25 |
| RS387907326 | Health Risk | Pathogenic | Inflammatory bowel disease 25, Inflammatory bowel disease 25 |
| RS920292604 | Health Risk | Pathogenic | Inflammatory bowel disease 25, Inflammatory bowel disease 25 |
| RS1329427406 | Health Risk | Pathogenic/Likely pathogenic | Inflammatory bowel disease 25, Inflammatory bowel disease 25 |
| RS2123561272 | Health Risk | Pathogenic/Likely pathogenic | Inflammatory bowel disease 25, Inflammatory bowel disease 25 |