IGF2BP3 Chromosome 7
Insulin like growth factor 2 mRNA binding protein 3
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What This Gene Does
The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
RNA binding motif containing
Locus Type
gene with protein product
Location
7p15.3
Ensembl
ENSG00000136231
Associated Conditions (1)
Vascular endothelial growth factor (VEGF) inhibitor response
All Variants (1)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS12700428 | Health Risk | association | Vascular endothelial growth factor (VEGF) inhibitor response, Vascular endothelial growth factor (VEGF) inhibitor response |