ICOSLG Chromosome 21
Inducible T cell costimulator ligand
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What This Gene Does
Enables identical protein binding activity and receptor ligand activity. Involved in T follicular helper cell differentiation. Located in intracellular membrane-bounded organelle. Is active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Gene Info
Gene Group
"CD molecules|Receptor ligands|V-set domain containing|C2-set domain containing|B7 family"
Locus Type
gene with protein product
Location
21q22.3
Ensembl
ENSG00000160223
Associated Conditions (2)
Inborn genetic diseases
Combined immunodeficiency
Key Variants
RS1055291520
Conflicting classifications of pathogenicity
Health Risk
RS140894768
Conflicting classifications of pathogenicity
Health Risk
RS186459476
Conflicting classifications of pathogenicity
Health Risk
RS199766847
Conflicting classifications of pathogenicity
Health Risk
RS199878735
Conflicting classifications of pathogenicity
Health Risk
RS201900032
Conflicting classifications of pathogenicity
Health Risk
RS376840764
Conflicting classifications of pathogenicity
Health Risk
RS566695508
Conflicting classifications of pathogenicity
Health Risk
RS760455624
Conflicting classifications of pathogenicity
Health Risk
RS764347085
Conflicting classifications of pathogenicity
Health Risk
RS772294235
Conflicting classifications of pathogenicity
Health Risk
RS1165558487
Likely pathogenic
Inborn genetic diseases, Inborn genetic diseases
Health Risk
All Variants (13)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1055291520 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS140894768 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS186459476 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS199766847 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS199878735 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS201900032 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS376840764 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS566695508 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS760455624 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS764347085 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS772294235 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS1165558487 | Health Risk | Likely pathogenic | Inborn genetic diseases, Inborn genetic diseases |
| RS2146342598 | Health Risk | Likely pathogenic | Combined immunodeficiency, Combined immunodeficiency |