ICOS Chromosome 2
Inducible T cell costimulator
Upload your DNA to see your personal genotypes for variants in ICOS.
What This Gene Does
The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
CD molecules
Locus Type
gene with protein product
Location
2q33.2
Ensembl
ENSG00000163600
Associated Conditions (6)
Immunodeficiency
common variable
1
ICOS-related disorder
Inherited Immunodeficiency Diseases
Cholangiocarcinoma
Key Variants
RS140049646
Conflicting classifications of pathogenicity
Immunodeficiency, common variable, 1
Health Risk
RS145698501
Conflicting classifications of pathogenicity
Immunodeficiency, common variable, 1
Health Risk
RS148435889
Conflicting classifications of pathogenicity
Immunodeficiency, common variable, 1
Health Risk
RS201031378
Conflicting classifications of pathogenicity
Immunodeficiency, common variable, 1
Health Risk
RS375299065
Conflicting classifications of pathogenicity
Inherited Immunodeficiency Diseases, Immunodeficiency, common variable
Health Risk
RS537195517
Conflicting classifications of pathogenicity
Immunodeficiency, common variable, 1
Health Risk
RS55655222
Conflicting classifications of pathogenicity
Immunodeficiency, common variable, 1
Health Risk
RS565719501
Conflicting classifications of pathogenicity
Immunodeficiency, common variable, 1
Health Risk
RS765158675
Conflicting classifications of pathogenicity
Immunodeficiency, common variable, 1
Health Risk
RS76778263
Conflicting classifications of pathogenicity
Immunodeficiency, common variable, 1
Health Risk
RS768500706
Conflicting classifications of pathogenicity
Immunodeficiency, common variable, 1
Health Risk
RS1559035937
Likely pathogenic
Immunodeficiency, common variable, 1
Health Risk
All Variants (21)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS140049646 | Health Risk | Conflicting classifications of pathogenicity | Immunodeficiency, common variable, 1 |
| RS145698501 | Health Risk | Conflicting classifications of pathogenicity | Immunodeficiency, common variable, 1 |
| RS148435889 | Health Risk | Conflicting classifications of pathogenicity | Immunodeficiency, common variable, 1 |
| RS201031378 | Health Risk | Conflicting classifications of pathogenicity | Immunodeficiency, common variable, 1 |
| RS375299065 | Health Risk | Conflicting classifications of pathogenicity | Inherited Immunodeficiency Diseases, Immunodeficiency, common variable |
| RS537195517 | Health Risk | Conflicting classifications of pathogenicity | Immunodeficiency, common variable, 1 |
| RS55655222 | Health Risk | Conflicting classifications of pathogenicity | Immunodeficiency, common variable, 1 |
| RS565719501 | Health Risk | Conflicting classifications of pathogenicity | Immunodeficiency, common variable, 1 |
| RS765158675 | Health Risk | Conflicting classifications of pathogenicity | Immunodeficiency, common variable, 1 |
| RS76778263 | Health Risk | Conflicting classifications of pathogenicity | Immunodeficiency, common variable, 1 |
| RS768500706 | Health Risk | Conflicting classifications of pathogenicity | Immunodeficiency, common variable, 1 |
| RS1559035937 | Health Risk | Likely pathogenic | Immunodeficiency, common variable, 1 |
| RS2469806956 | Health Risk | Likely pathogenic | Immunodeficiency, common variable, 1 |
| RS757598952 | Health Risk | Likely pathogenic | Immunodeficiency, common variable, 1 |
| RS1015881666 | Health Risk | Pathogenic | Immunodeficiency, common variable, 1 |
| RS1690066397 | Health Risk | Pathogenic | Immunodeficiency, common variable, 1 |
| RS2105754294 | Health Risk | Pathogenic | Immunodeficiency, common variable, 1 |
| RS2469780660 | Health Risk | Pathogenic | Immunodeficiency, common variable, 1 |
| RS2469807349 | Health Risk | Pathogenic | Immunodeficiency, common variable, 1 |
| RS2469807419 | Health Risk | Pathogenic | Immunodeficiency, common variable, 1 |
| RS778146668 | Health Risk | Pathogenic | Immunodeficiency, common variable, 1 |