HTR1A Chromosome 5
5-hydroxytryptamine receptor 1A
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What This Gene Does
This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers. [provided by RefSeq, Jun 2012]
Gene Info
Gene Group
5-hydroxytryptamine receptors, G protein-coupled
Locus Type
gene with protein product
Location
5q12.3
Ensembl
ENSG00000178394
Associated Conditions (1)
Menstrual cycle-dependent periodic fever
Key Variants
RS201899093
Conflicting classifications of pathogenicity
Menstrual cycle-dependent periodic fever, Menstrual cycle-dependent periodic fever
Health Risk
RS367956927
Conflicting classifications of pathogenicity
Menstrual cycle-dependent periodic fever, Menstrual cycle-dependent periodic fever
Health Risk
All Variants (2)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS201899093 | Health Risk | Conflicting classifications of pathogenicity | Menstrual cycle-dependent periodic fever, Menstrual cycle-dependent periodic fever |
| RS367956927 | Health Risk | Conflicting classifications of pathogenicity | Menstrual cycle-dependent periodic fever, Menstrual cycle-dependent periodic fever |