HS3ST1 Chromosome 4
Heparan sulfate-glucosamine 3-sulfotransferase 1
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What This Gene Does
Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It possesses both heparan sulfate glucosaminyl 3-O-sulfotransferase activity, anticoagulant heparan sulfate conversion activity, and is a rate limiting enzyme for synthesis of anticoagulant heparan. This enzyme is an intraluminal Golgi resident protein. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
Sulfotransferases, membrane bound
Locus Type
gene with protein product
Location
4p15.33
Ensembl
ENSG00000002587
Associated Conditions (2)
Arteriosclerosis disorder
Coronary artery disorder
Key Variants
All Variants (1)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS16881446 | Health Risk | risk factor | Arteriosclerosis disorder, Coronary artery disorder, Arteriosclerosis disorder |