HLA-G Chromosome 6
Major histocompatibility complex, class I, G
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What This Gene Does
HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
"Histocompatibility complex|C1-set domain containing"
Locus Type
gene with protein product
Location
6p22.1
Ensembl
ENSG00000204632
Associated Conditions (1)
Post-COVID-19 disorder
Key Variants
All Variants (1)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS371194629 | Health Risk | Likely risk allele | Post-COVID-19 disorder, Post-COVID-19 disorder |