HFM1 Chromosome 1
Helicase for meiosis 1
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What This Gene Does
The protein encoded by this gene is thought to be an ATP-dependent DNA helicase and is expressed mainly in germ-line cells. Defects in this gene are a cause of premature ovarian failure 9 (POF9). [provided by RefSeq, Apr 2014]
Associated Conditions (4)
Premature ovarian failure 9
Genetic non-acquired premature ovarian failure
Azoospermia
Spermatogenic failure 4
Key Variants
RS74938180
Conflicting classifications of pathogenicity
Premature ovarian failure 9, Premature ovarian failure 9
Health Risk
RS1209622397
Likely pathogenic
Genetic non-acquired premature ovarian failure, Genetic non-acquired premature ovarian failure
Health Risk
RS2525301718
Likely pathogenic
Premature ovarian failure 9, Premature ovarian failure 9
Health Risk
RS754924716
Likely pathogenic
Premature ovarian failure 9, Premature ovarian failure 9
Health Risk
RS763202322
Likely pathogenic
Premature ovarian failure 9, Premature ovarian failure 9
Health Risk
RS763964671
Likely pathogenic
Premature ovarian failure 9, Premature ovarian failure 9
Health Risk
RS2101730664
Pathogenic
Genetic non-acquired premature ovarian failure, Genetic non-acquired premature ovarian failure
Health Risk
RS587777268
Pathogenic
Premature ovarian failure 9, Premature ovarian failure 9
Health Risk
RS587777269
Pathogenic
Premature ovarian failure 9, Premature ovarian failure 9
Health Risk
RS587777270
Pathogenic
Premature ovarian failure 9, Premature ovarian failure 9
Health Risk
RS730880018
Pathogenic
Premature ovarian failure 9, Premature ovarian failure 9
Health Risk
RS746229304
Pathogenic
Azoospermia, Azoospermia
Health Risk
All Variants (15)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS74938180 | Health Risk | Conflicting classifications of pathogenicity | Premature ovarian failure 9, Premature ovarian failure 9 |
| RS1209622397 | Health Risk | Likely pathogenic | Genetic non-acquired premature ovarian failure, Genetic non-acquired premature ovarian failure |
| RS2525301718 | Health Risk | Likely pathogenic | Premature ovarian failure 9, Premature ovarian failure 9 |
| RS754924716 | Health Risk | Likely pathogenic | Premature ovarian failure 9, Premature ovarian failure 9 |
| RS763202322 | Health Risk | Likely pathogenic | Premature ovarian failure 9, Premature ovarian failure 9 |
| RS763964671 | Health Risk | Likely pathogenic | Premature ovarian failure 9, Premature ovarian failure 9 |
| RS2101730664 | Health Risk | Pathogenic | Genetic non-acquired premature ovarian failure, Genetic non-acquired premature ovarian failure |
| RS587777268 | Health Risk | Pathogenic | Premature ovarian failure 9, Premature ovarian failure 9 |
| RS587777269 | Health Risk | Pathogenic | Premature ovarian failure 9, Premature ovarian failure 9 |
| RS587777270 | Health Risk | Pathogenic | Premature ovarian failure 9, Premature ovarian failure 9 |
| RS730880018 | Health Risk | Pathogenic | Premature ovarian failure 9, Premature ovarian failure 9 |
| RS746229304 | Health Risk | Pathogenic | Azoospermia, Azoospermia |
| RS748343941 | Health Risk | Pathogenic | Spermatogenic failure 4, Spermatogenic failure 4 |
| RS751622198 | Health Risk | Pathogenic | Premature ovarian failure 9, Premature ovarian failure 9 |
| RS753422559 | Health Risk | Pathogenic | Spermatogenic failure 4, Spermatogenic failure 4 |