HDC Chromosome 15

Histidine decarboxylase

2 variants 2 Health Risk

Upload your DNA to see your personal genotypes for variants in HDC.

What This Gene Does

This gene encodes a member of the group II decarboxylase family and forms a homodimer that converts L-histidine to histamine in a pyridoxal phosphate dependent manner. Histamine regulates several physiologic processes, including neurotransmission, gastric acid secretion,inflamation, and smooth muscle tone.[provided by RefSeq, Aug 2010]

Associated Conditions (1)

Tourette syndrome

Key Variants

RS2509380645

Likely pathogenic

Tourette syndrome, Tourette syndrome

Health Risk

RS267606861

Pathogenic

Tourette syndrome, Tourette syndrome

Health Risk

All Variants (2)

RSID	Category	Clinical Significance	Conditions
RS2509380645	Health Risk	Likely pathogenic	Tourette syndrome, Tourette syndrome
RS267606861	Health Risk	Pathogenic	Tourette syndrome, Tourette syndrome