GSTT2 Chromosome 22
Glutathione S-transferase theta 2 (gene/pseudogene)
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What This Gene Does
The protein encoded by this gene, glutathione S-transferase (GST) theta 2 (GSTT2), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT2 and GSTT2B are nearly identical to each other, and share 55% amino acid identity with GSTT1. All three genes may play a role in human carcinogenesis. The GSTT2 gene is a pseudogene in some populations. [provided by RefSeq, Sep 2015]
Gene Info
Gene Group
Soluble glutathione S-transferases
Locus Type
gene with protein product
Location
22q11.23
Ensembl
ENSG00000099984
Associated Conditions (1)
Megalencephalic leukoencephalopathy with subcortical cysts 1
All Variants (1)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS181983734 | Health Risk | Likely pathogenic | Megalencephalic leukoencephalopathy with subcortical cysts 1, Megalencephalic leukoencephalopathy with subcortical cysts 1 |