GRAMD1B Chromosome 11

GRAM domain containing 1B

1 variant 1 Health Risk

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What This Gene Does

Predicted to enable cholesterol binding activity; cholesterol transfer activity; and phospholipid binding activity. Predicted to be involved in cellular response to cholesterol; cholesterol homeostasis; and intracellular sterol transport. Located in endoplasmic reticulum membrane; endoplasmic reticulum-plasma membrane contact site; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Gene Info

Gene Group

GRAM domain containing

Locus Type

gene with protein product

Location

11q24.1

Ensembl

ENSG00000023171

Associated Conditions (1)

Intellectual disability

Key Variants

RS1951071576

Likely pathogenic

Intellectual disability, Intellectual disability

Health Risk

All Variants (1)

RSID	Category	Clinical Significance	Conditions
RS1951071576	Health Risk	Likely pathogenic	Intellectual disability, Intellectual disability