GAL3ST2 Chromosome 2
Galactose-3-O-sulfotransferase 2
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What This Gene Does
This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate group to the hydroxyl at C-3 of nonreducing beta-galactosyl residues, and it can act on both type 1 and type 2 (Galbeta 1-3/1-4GlcNAc-R) oligosaccharides with similar efficiencies, and on core 1 glycans. This enzyme has been implicated in tumor metastasis processes. This gene is different from the GAL3ST3 gene located on chromosome 11, which has also been referred to as GAL3ST2 and encodes a related enzyme with distinct tissue distribution and substrate specificities, compared to galactose-3-O-sulfotransferase 2. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
Sulfotransferases, membrane bound
Locus Type
gene with protein product
Location
2q37.3
Ensembl
ENSG00000154252
Associated Conditions (4)
Ovarian serous cystadenocarcinoma
Cervical cancer
Chronic lymphocytic leukemia/small lymphocytic lymphoma
Acute myeloid leukemia
Key Variants
All Variants (2)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS78620448 | Health Risk | Conflicting classifications of pathogenicity | Ovarian serous cystadenocarcinoma, Cervical cancer, Chronic lymphocytic leukemia/small lymphocytic lymphoma |
| RS372108744 | Health Risk | Likely pathogenic | — |