FSIP2 Chromosome 2

Fibrous sheath interacting protein 2

23 variants 23 Health Risk

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What This Gene Does

This gene encodes a protein associated with the sperm fibrous sheath. Genes encoding most of the fibrous-sheath associated proteins genes are transcribed only during the postmeiotic period of spermatogenesis. The protein encoded by this gene is specific to spermatogenic cells. Copy number variation in this gene may be associated with testicular germ cell tumors. Pseudogenes associated with this gene are reported on chromosomes 2 and X. [provided by RefSeq, Aug 2016]

Associated Conditions (2)

Spermatogenic failure 34

FSIP2-related disorder

Key Variants

RS111265848

Conflicting classifications of pathogenicity

Health Risk

RS113773415

Conflicting classifications of pathogenicity

Health Risk

RS141318533

Conflicting classifications of pathogenicity

Spermatogenic failure 34, FSIP2-related disorder, Spermatogenic failure 34

Health Risk

RS142306380

Conflicting classifications of pathogenicity

Spermatogenic failure 34, FSIP2-related disorder, Spermatogenic failure 34

Health Risk

RS142675481

Conflicting classifications of pathogenicity

Health Risk

RS200352552

Conflicting classifications of pathogenicity

Health Risk

RS201876794

Conflicting classifications of pathogenicity

Health Risk

RS551594235

Conflicting classifications of pathogenicity

Health Risk

RS996638473

Conflicting classifications of pathogenicity

Health Risk

Health Risk

Spermatogenic failure 34, Spermatogenic failure 34

Health Risk

RS745571898

Likely pathogenic

Spermatogenic failure 34, Spermatogenic failure 34

Health Risk

All Variants (23)

RSID	Category	Clinical Significance	Conditions
RS111265848	Health Risk	Conflicting classifications of pathogenicity	—
RS113773415	Health Risk	Conflicting classifications of pathogenicity	—
RS141318533	Health Risk	Conflicting classifications of pathogenicity	Spermatogenic failure 34, FSIP2-related disorder, Spermatogenic failure 34
RS142306380	Health Risk	Conflicting classifications of pathogenicity	Spermatogenic failure 34, FSIP2-related disorder, Spermatogenic failure 34
RS142675481	Health Risk	Conflicting classifications of pathogenicity	FSIP2-related disorder, FSIP2-related disorder
RS200352552	Health Risk	Conflicting classifications of pathogenicity	—
RS201876794	Health Risk	Conflicting classifications of pathogenicity	FSIP2-related disorder, FSIP2-related disorder
RS551594235	Health Risk	Conflicting classifications of pathogenicity	FSIP2-related disorder, FSIP2-related disorder
RS996638473	Health Risk	Conflicting classifications of pathogenicity	—
RS1210297170	Health Risk	Likely pathogenic	—
RS2468724359	Health Risk	Likely pathogenic	Spermatogenic failure 34, Spermatogenic failure 34
RS745571898	Health Risk	Likely pathogenic	Spermatogenic failure 34, Spermatogenic failure 34
RS1218883375	Health Risk	Pathogenic	Spermatogenic failure 34, Spermatogenic failure 34
RS1325784701	Health Risk	Pathogenic	Spermatogenic failure 34, Spermatogenic failure 34
RS1559024613	Health Risk	Pathogenic	Spermatogenic failure 34, Spermatogenic failure 34
RS1559025141	Health Risk	Pathogenic	Spermatogenic failure 34, Spermatogenic failure 34
RS1559034750	Health Risk	Pathogenic	Spermatogenic failure 34, Spermatogenic failure 34
RS191083003	Health Risk	Pathogenic	Spermatogenic failure 34, Spermatogenic failure 34
RS2468750474	Health Risk	Pathogenic	Spermatogenic failure 34, Spermatogenic failure 34
RS2468764436	Health Risk	Pathogenic	Spermatogenic failure 34, Spermatogenic failure 34
RS527302772	Health Risk	Pathogenic	Spermatogenic failure 34, Spermatogenic failure 34
RS558463276	Health Risk	Pathogenic	Spermatogenic failure 34, Spermatogenic failure 34
RS773975635	Health Risk	Pathogenic	Spermatogenic failure 34, Spermatogenic failure 34