FLT4 Chromosome 5

Fms related receptor tyrosine kinase 4

48 variants 1 Drug Response 47 Health Risk

Upload your DNA to see your personal genotypes for variants in FLT4.

What This Gene Does

This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. [provided by RefSeq, Jul 2008]

Gene Info

Gene Group

"Receptor tyrosine kinases|I-set domain containing"

Locus Type

gene with protein product

Location

5q35.3

Ensembl

ENSG00000037280

Associated Conditions (10)

Regorafenib response

FLT4-related disorder

Inborn genetic diseases

Hereditary lymphedema type I

Lymphedema

Capillary infantile hemangioma

Congenital heart defects

multiple types

Non-immune hydrops fetalis

Key Variants

RS1554115894

drug response

Regorafenib response, Regorafenib response

Drug Response

RS143163262

Conflicting classifications of pathogenicity

Health Risk

RS143813005

Conflicting classifications of pathogenicity

Inborn genetic diseases, Inborn genetic diseases

Health Risk

RS146167161

Conflicting classifications of pathogenicity

Hereditary lymphedema type I, Hereditary lymphedema type I

Health Risk

RS149033942

Conflicting classifications of pathogenicity

Health Risk

RS200763913

Conflicting classifications of pathogenicity

Health Risk

RS566339142

Conflicting classifications of pathogenicity

Health Risk

RS767952525

Conflicting classifications of pathogenicity

Inborn genetic diseases, Inborn genetic diseases

Health Risk

RS773696166

Conflicting classifications of pathogenicity

Lymphedema, Lymphedema

Health Risk

RS121909652

Likely pathogenic

Hereditary lymphedema type I, Hereditary lymphedema type I

Health Risk

Health Risk

Inborn genetic diseases, Inborn genetic diseases

Health Risk

All Variants (48)

RSID	Category	Clinical Significance	Conditions
RS1554115894	Drug Response	drug response	Regorafenib response, Regorafenib response
RS143163262	Health Risk	Conflicting classifications of pathogenicity	FLT4-related disorder, Inborn genetic diseases, FLT4-related disorder
RS143813005	Health Risk	Conflicting classifications of pathogenicity	Inborn genetic diseases, Inborn genetic diseases
RS146167161	Health Risk	Conflicting classifications of pathogenicity	Hereditary lymphedema type I, Hereditary lymphedema type I
RS149033942	Health Risk	Conflicting classifications of pathogenicity	FLT4-related disorder, Hereditary lymphedema type I, FLT4-related disorder
RS200763913	Health Risk	Conflicting classifications of pathogenicity	—
RS566339142	Health Risk	Conflicting classifications of pathogenicity	—
RS767952525	Health Risk	Conflicting classifications of pathogenicity	Inborn genetic diseases, Inborn genetic diseases
RS773696166	Health Risk	Conflicting classifications of pathogenicity	Lymphedema, Lymphedema
RS121909652	Health Risk	Likely pathogenic	Hereditary lymphedema type I, Hereditary lymphedema type I
RS1302178938	Health Risk	Likely pathogenic	—
RS1554109707	Health Risk	Likely pathogenic	Inborn genetic diseases, Inborn genetic diseases
RS1761973773	Health Risk	Likely pathogenic	Hereditary lymphedema type I, Hereditary lymphedema type I
RS1762335528	Health Risk	Likely pathogenic	Hereditary lymphedema type I, Capillary infantile hemangioma, Congenital heart defects
RS1764039505	Health Risk	Likely pathogenic	Congenital heart defects, multiple types, 7
RS2127781697	Health Risk	Likely pathogenic	—
RS2127787560	Health Risk	Likely pathogenic	FLT4-related disorder, FLT4-related disorder
RS2127802292	Health Risk	Likely pathogenic	—
RS2480849793	Health Risk	Likely pathogenic	—
RS2480864921	Health Risk	Likely pathogenic	—
RS2480865039	Health Risk	Likely pathogenic	—
RS2480880177	Health Risk	Likely pathogenic	Congenital heart defects, multiple types, 7
RS2480886920	Health Risk	Likely pathogenic	Hereditary lymphedema type I, Hereditary lymphedema type I
RS2480904044	Health Risk	Likely pathogenic	—
RS2480922403	Health Risk	Likely pathogenic	FLT4-related disorder, FLT4-related disorder
RS2480933426	Health Risk	Likely pathogenic	FLT4-related disorder, FLT4-related disorder
RS2480983963	Health Risk	Likely pathogenic	Congenital heart defects, multiple types, 7
RS121909651	Health Risk	Pathogenic	Hereditary lymphedema type I, Hereditary lymphedema type I
RS121909653	Health Risk	Pathogenic	Hereditary lymphedema type I, Hereditary lymphedema type I
RS121909654	Health Risk	Pathogenic	Hereditary lymphedema type I, Hereditary lymphedema type I
RS121909656	Health Risk	Pathogenic	Hereditary lymphedema type I, Hereditary lymphedema type I
RS1415338572	Health Risk	Pathogenic	Congenital heart defects, multiple types, 7
RS1422886839	Health Risk	Pathogenic	Congenital heart defects, multiple types, 7
RS1581616817	Health Risk	Pathogenic	Congenital heart defects, multiple types, 7
RS1581655293	Health Risk	Pathogenic	Congenital heart defects, multiple types, 7
RS2127839096	Health Risk	Pathogenic	Congenital heart defects, multiple types, 7
RS2480842959	Health Risk	Pathogenic	Hereditary lymphedema type I, Hereditary lymphedema type I
RS2480865554	Health Risk	Pathogenic	Hereditary lymphedema type I, Hereditary lymphedema type I
RS2480869226	Health Risk	Pathogenic	FLT4-related disorder, FLT4-related disorder
RS2480883778	Health Risk	Pathogenic	FLT4-related disorder, FLT4-related disorder
RS2480884226	Health Risk	Pathogenic	Hereditary lymphedema type I, Hereditary lymphedema type I
RS267606818	Health Risk	Pathogenic	Hereditary lymphedema type I, Hereditary lymphedema type I
RS755445139	Health Risk	Pathogenic	Congenital heart defects, multiple types, 7
RS121909650	Health Risk	Pathogenic/Likely pathogenic	Hereditary lymphedema type I, FLT4-related disorder, Hereditary lymphedema type I
RS121909655	Health Risk	Pathogenic/Likely pathogenic	Hereditary lymphedema type I, FLT4-related disorder, Hereditary lymphedema type I
RS1451816005	Health Risk	Pathogenic/Likely pathogenic	Hereditary lymphedema type I, FLT4-related disorder, Non-immune hydrops fetalis
RS146006663	Health Risk	Pathogenic/Likely pathogenic	Congenital heart defects, multiple types, 7
RS587776833	Health Risk	Pathogenic/Likely pathogenic	Hereditary lymphedema type I, Hereditary lymphedema type I