FKBP5 Chromosome 6
FKBP prolyl isomerase 5
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What This Gene Does
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
Gene Info
Gene Group
"Tetratricopeptide repeat domain containing|FKBP prolyl isomerase family|MicroRNA protein coding host genes"
Locus Type
gene with protein product
Location
6p21.31
Ensembl
ENSG00000096060
Associated Conditions (5)
Antidepressant drug treatment
accelerated response to
Post-traumatic stress disorder
Susceptibility to severe depressive disorder
Asthma
Key Variants
RS1360780
Likely risk allele
Antidepressant drug treatment, accelerated response to, Post-traumatic stress disorder
Health Risk
RS4713902
Likely risk allele
Susceptibility to severe depressive disorder, Susceptibility to severe depressive disorder
Health Risk
RS4713916
Likely risk allele
Susceptibility to severe depressive disorder, Susceptibility to severe depressive disorder
Health Risk
RS6926133
Likely risk allele
Susceptibility to severe depressive disorder, Susceptibility to severe depressive disorder
Health Risk
RS737054
Likely risk allele
Susceptibility to severe depressive disorder, Susceptibility to severe depressive disorder
Health Risk
RS9380525
Likely risk allele
Susceptibility to severe depressive disorder, Susceptibility to severe depressive disorder
Health Risk
RS9470079
Likely risk allele
Susceptibility to severe depressive disorder, Susceptibility to severe depressive disorder
Health Risk
RS1581842283
risk factor
Asthma, Asthma
Health Risk
All Variants (8)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1360780 | Health Risk | Likely risk allele | Antidepressant drug treatment, accelerated response to, Post-traumatic stress disorder |
| RS4713902 | Health Risk | Likely risk allele | Susceptibility to severe depressive disorder, Susceptibility to severe depressive disorder |
| RS4713916 | Health Risk | Likely risk allele | Susceptibility to severe depressive disorder, Susceptibility to severe depressive disorder |
| RS6926133 | Health Risk | Likely risk allele | Susceptibility to severe depressive disorder, Susceptibility to severe depressive disorder |
| RS737054 | Health Risk | Likely risk allele | Susceptibility to severe depressive disorder, Susceptibility to severe depressive disorder |
| RS9380525 | Health Risk | Likely risk allele | Susceptibility to severe depressive disorder, Susceptibility to severe depressive disorder |
| RS9470079 | Health Risk | Likely risk allele | Susceptibility to severe depressive disorder, Susceptibility to severe depressive disorder |
| RS1581842283 | Health Risk | risk factor | Asthma, Asthma |