FCGR2B Chromosome 1
Fc gamma receptor IIb
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What This Gene Does
The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Gene Info
Gene Group
"CD molecules|Immunoglobulin like domain containing|Fc receptors"
Locus Type
gene with protein product
Location
1q23.3
Ensembl
ENSG00000072694
Associated Conditions (4)
Systemic lupus erythematosus
susceptibility to
Malaria
resistance to
Key Variants
RS144573139
Conflicting classifications of pathogenicity
Health Risk
RS5017568
Conflicting classifications of pathogenicity
Health Risk
RS3219018
risk factor
Systemic lupus erythematosus, susceptibility to, Systemic lupus erythematosus
Health Risk
RS1050501
protective; risk factor
Systemic lupus erythematosus, susceptibility to, Malaria
Protective
All Variants (4)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS144573139 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS5017568 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS3219018 | Health Risk | risk factor | Systemic lupus erythematosus, susceptibility to, Systemic lupus erythematosus |
| RS1050501 | Protective | protective; risk factor | Systemic lupus erythematosus, susceptibility to, Malaria |