FASLG Chromosome 1
Fas ligand
Upload your DNA to see your personal genotypes for variants in FASLG.
What This Gene Does
This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2014]
Gene Info
Gene Group
"CD molecules|Tumor necrosis factor superfamily|Death inducing signaling complex"
Locus Type
gene with protein product
Location
1q24.3
Ensembl
ENSG00000117560
Associated Conditions (7)
Autoimmune lymphoproliferative syndrome type 1
FASLG-related disorder
Lung cancer
AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME
TYPE IB
LUNG CANCER
SUSCEPTIBILITY TO
Key Variants
RS140406512
Conflicting classifications of pathogenicity
Autoimmune lymphoproliferative syndrome type 1, FASLG-related disorder, Autoimmune lymphoproliferative syndrome type 1
Health Risk
RS201525996
Conflicting classifications of pathogenicity
Autoimmune lymphoproliferative syndrome type 1, Lung cancer, Autoimmune lymphoproliferative syndrome type 1
Health Risk
RS372615226
Conflicting classifications of pathogenicity
Autoimmune lymphoproliferative syndrome type 1, Autoimmune lymphoproliferative syndrome type 1
Health Risk
RS375737004
Conflicting classifications of pathogenicity
Autoimmune lymphoproliferative syndrome type 1, Autoimmune lymphoproliferative syndrome type 1
Health Risk
RS56302117
Conflicting classifications of pathogenicity
Autoimmune lymphoproliferative syndrome type 1, Autoimmune lymphoproliferative syndrome type 1
Health Risk
RS758796005
Conflicting classifications of pathogenicity
Autoimmune lymphoproliferative syndrome type 1, AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME, TYPE IB
Health Risk
RS759351686
Conflicting classifications of pathogenicity
Autoimmune lymphoproliferative syndrome type 1, Autoimmune lymphoproliferative syndrome type 1
Health Risk
RS1413244355
Likely pathogenic
Autoimmune lymphoproliferative syndrome type 1, Lung cancer, Autoimmune lymphoproliferative syndrome type 1
Health Risk
RS2527587918
Pathogenic
Autoimmune lymphoproliferative syndrome type 1, Autoimmune lymphoproliferative syndrome type 1
Health Risk
RS773045347
Pathogenic
Autoimmune lymphoproliferative syndrome type 1, Autoimmune lymphoproliferative syndrome type 1
Health Risk
RS80358236
Pathogenic
AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME, TYPE IB, Autoimmune lymphoproliferative syndrome type 1
Health Risk
RS763110
risk factor
LUNG CANCER, SUSCEPTIBILITY TO, LUNG CANCER
Health Risk
All Variants (12)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS140406512 | Health Risk | Conflicting classifications of pathogenicity | Autoimmune lymphoproliferative syndrome type 1, FASLG-related disorder, Autoimmune lymphoproliferative syndrome type 1 |
| RS201525996 | Health Risk | Conflicting classifications of pathogenicity | Autoimmune lymphoproliferative syndrome type 1, Lung cancer, Autoimmune lymphoproliferative syndrome type 1 |
| RS372615226 | Health Risk | Conflicting classifications of pathogenicity | Autoimmune lymphoproliferative syndrome type 1, Autoimmune lymphoproliferative syndrome type 1 |
| RS375737004 | Health Risk | Conflicting classifications of pathogenicity | Autoimmune lymphoproliferative syndrome type 1, Autoimmune lymphoproliferative syndrome type 1 |
| RS56302117 | Health Risk | Conflicting classifications of pathogenicity | Autoimmune lymphoproliferative syndrome type 1, Autoimmune lymphoproliferative syndrome type 1 |
| RS758796005 | Health Risk | Conflicting classifications of pathogenicity | Autoimmune lymphoproliferative syndrome type 1, AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME, TYPE IB |
| RS759351686 | Health Risk | Conflicting classifications of pathogenicity | Autoimmune lymphoproliferative syndrome type 1, Autoimmune lymphoproliferative syndrome type 1 |
| RS1413244355 | Health Risk | Likely pathogenic | Autoimmune lymphoproliferative syndrome type 1, Lung cancer, Autoimmune lymphoproliferative syndrome type 1 |
| RS2527587918 | Health Risk | Pathogenic | Autoimmune lymphoproliferative syndrome type 1, Autoimmune lymphoproliferative syndrome type 1 |
| RS773045347 | Health Risk | Pathogenic | Autoimmune lymphoproliferative syndrome type 1, Autoimmune lymphoproliferative syndrome type 1 |
| RS80358236 | Health Risk | Pathogenic | AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME, TYPE IB, Autoimmune lymphoproliferative syndrome type 1 |
| RS763110 | Health Risk | risk factor | LUNG CANCER, SUSCEPTIBILITY TO, LUNG CANCER |