FANCG Chromosome 9
FA complementation group G
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What This Gene Does
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group G. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
"FA complementation groups|FA core complex"
Locus Type
gene with protein product
Location
9p13.3
Ensembl
ENSG00000221829
Associated Conditions (10)
Fanconi anemia complementation group G
Fanconi anemia
Inborn genetic diseases
FANCG-related disorder
Ovarian cancer
Pituitary stalk interruption syndrome
Carcinoma of pancreas
Abnormality of blood and blood-forming tissues
Monogenic short statue
Lymphoma
Key Variants
RS1217203217
Conflicting classifications of pathogenicity
Fanconi anemia complementation group G, Fanconi anemia, Inborn genetic diseases
Health Risk
RS1276088946
Conflicting classifications of pathogenicity
Fanconi anemia, Fanconi anemia complementation group G, Inborn genetic diseases
Health Risk
RS138395184
Conflicting classifications of pathogenicity
Inborn genetic diseases, Fanconi anemia, Fanconi anemia complementation group G
Health Risk
RS138855718
Conflicting classifications of pathogenicity
Fanconi anemia, Fanconi anemia complementation group G, FANCG-related disorder
Health Risk
RS1404150675
Conflicting classifications of pathogenicity
Fanconi anemia complementation group G, Fanconi anemia, Fanconi anemia complementation group G
Health Risk
RS141147618
Conflicting classifications of pathogenicity
Fanconi anemia, Fanconi anemia complementation group G, Ovarian cancer
Health Risk
RS145092954
Conflicting classifications of pathogenicity
Fanconi anemia, Fanconi anemia complementation group G, Inborn genetic diseases
Health Risk
RS1563984976
Conflicting classifications of pathogenicity
Fanconi anemia, Fanconi anemia complementation group G, Fanconi anemia
Health Risk
RS17878854
Conflicting classifications of pathogenicity
Fanconi anemia, Fanconi anemia complementation group G, Fanconi anemia
Health Risk
RS17880082
Conflicting classifications of pathogenicity
Fanconi anemia, Fanconi anemia complementation group G, FANCG-related disorder
Health Risk
RS17885240
Conflicting classifications of pathogenicity
Fanconi anemia, Fanconi anemia complementation group G, FANCG-related disorder
Health Risk
RS1829075705
Conflicting classifications of pathogenicity
Fanconi anemia, Inborn genetic diseases, Fanconi anemia
Health Risk
All Variants (202)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1829091761 | Health Risk | Likely pathogenic | Fanconi anemia, Fanconi anemia |
| RS1829129603 | Health Risk | Likely pathogenic | Fanconi anemia complementation group G, Pituitary stalk interruption syndrome, Fanconi anemia |
| RS1829144030 | Health Risk | Likely pathogenic | Fanconi anemia, Fanconi anemia |
| RS1829145397 | Health Risk | Likely pathogenic | Fanconi anemia complementation group G, Fanconi anemia complementation group G |
| RS200479612 | Health Risk | Likely pathogenic | Fanconi anemia complementation group G, Fanconi anemia, Fanconi anemia complementation group G |
| RS2131051986 | Health Risk | Likely pathogenic | Fanconi anemia, Fanconi anemia |
| RS2131051989 | Health Risk | Likely pathogenic | Fanconi anemia, Fanconi anemia |
| RS2131053141 | Health Risk | Likely pathogenic | Fanconi anemia, Fanconi anemia |
| RS2131053808 | Health Risk | Likely pathogenic | Fanconi anemia, Fanconi anemia |
| RS2131053817 | Health Risk | Likely pathogenic | Fanconi anemia, Fanconi anemia |
| RS2131055534 | Health Risk | Likely pathogenic | Fanconi anemia complementation group G, Fanconi anemia complementation group G |
| RS2131055994 | Health Risk | Likely pathogenic | Fanconi anemia complementation group G, Fanconi anemia complementation group G |
| RS2131056131 | Health Risk | Likely pathogenic | Carcinoma of pancreas, Carcinoma of pancreas |
| RS2131056491 | Health Risk | Likely pathogenic | Fanconi anemia complementation group G, Fanconi anemia complementation group G |
| RS2131056701 | Health Risk | Likely pathogenic | Fanconi anemia, Abnormality of blood and blood-forming tissues, Fanconi anemia |
| RS2131057155 | Health Risk | Likely pathogenic | Fanconi anemia complementation group G, Fanconi anemia complementation group G |
| RS2131059176 | Health Risk | Likely pathogenic | Fanconi anemia, Fanconi anemia |
| RS2490392724 | Health Risk | Likely pathogenic | Fanconi anemia, Fanconi anemia |
| RS2490393648 | Health Risk | Likely pathogenic | Fanconi anemia complementation group G, Fanconi anemia complementation group G |
| RS2490393857 | Health Risk | Likely pathogenic | Fanconi anemia, Fanconi anemia |
| RS2490395865 | Health Risk | Likely pathogenic | Fanconi anemia complementation group G, Fanconi anemia complementation group G |
| RS2490396692 | Health Risk | Likely pathogenic | Fanconi anemia, Fanconi anemia |
| RS2490401471 | Health Risk | Likely pathogenic | Fanconi anemia complementation group G, Fanconi anemia complementation group G |
| RS2490401769 | Health Risk | Likely pathogenic | Fanconi anemia, Fanconi anemia, Fanconi anemia |
| RS2490402417 | Health Risk | Likely pathogenic | Fanconi anemia complementation group G, Fanconi anemia complementation group G |
| RS2490403470 | Health Risk | Likely pathogenic | Fanconi anemia complementation group G, Fanconi anemia complementation group G |
| RS2490403680 | Health Risk | Likely pathogenic | Fanconi anemia complementation group G, Fanconi anemia complementation group G |
| RS2490404555 | Health Risk | Likely pathogenic | Fanconi anemia complementation group G, Fanconi anemia complementation group G |
| RS2490407241 | Health Risk | Likely pathogenic | Fanconi anemia complementation group G, Fanconi anemia complementation group G |
| RS2490407836 | Health Risk | Likely pathogenic | Fanconi anemia complementation group G, Fanconi anemia complementation group G |
| RS2490408612 | Health Risk | Likely pathogenic | Fanconi anemia complementation group G, Fanconi anemia complementation group G |
| RS2490408677 | Health Risk | Likely pathogenic | Fanconi anemia complementation group G, Fanconi anemia complementation group G |
| RS2490408947 | Health Risk | Likely pathogenic | Fanconi anemia complementation group G, Fanconi anemia complementation group G |
| RS2490410471 | Health Risk | Likely pathogenic | Fanconi anemia complementation group G, Fanconi anemia complementation group G |
| RS2490410542 | Health Risk | Likely pathogenic | Fanconi anemia complementation group G, Fanconi anemia complementation group G |
| RS546023787 | Health Risk | Likely pathogenic | Fanconi anemia, Fanconi anemia complementation group G, Fanconi anemia complementation group G |
| RS587778345 | Health Risk | Likely pathogenic | Fanconi anemia complementation group G, Fanconi anemia complementation group G |
| RS746392434 | Health Risk | Likely pathogenic | Fanconi anemia complementation group G, Fanconi anemia complementation group G |
| RS764658302 | Health Risk | Likely pathogenic | Fanconi anemia complementation group G, Fanconi anemia complementation group G |
| RS765150956 | Health Risk | Likely pathogenic | Fanconi anemia complementation group G, Fanconi anemia complementation group G |
| RS766086210 | Health Risk | Likely pathogenic | Fanconi anemia complementation group G, Ovarian cancer, Fanconi anemia complementation group G |
| RS767443643 | Health Risk | Likely pathogenic | Fanconi anemia, Fanconi anemia complementation group G, Fanconi anemia |
| RS780502064 | Health Risk | Likely pathogenic | Ovarian cancer, Ovarian cancer |
| RS786204205 | Health Risk | Likely pathogenic | Fanconi anemia, Fanconi anemia complementation group G, Fanconi anemia |
| RS1018027137 | Health Risk | Pathogenic | Fanconi anemia, Fanconi anemia complementation group G, Fanconi anemia |
| RS1157985962 | Health Risk | Pathogenic | Fanconi anemia, Fanconi anemia |
| RS1187674541 | Health Risk | Pathogenic | Fanconi anemia, Fanconi anemia |
| RS1209807088 | Health Risk | Pathogenic | Fanconi anemia, Fanconi anemia complementation group G, Fanconi anemia |
| RS121434425 | Health Risk | Pathogenic | Fanconi anemia complementation group G, Fanconi anemia, Fanconi anemia complementation group G |
| RS121434426 | Health Risk | Pathogenic | Fanconi anemia complementation group G, Fanconi anemia, Fanconi anemia complementation group G |