FANCC Chromosome 9

FA complementation group C
371 variants 371 Health Risk

Upload your DNA to see your personal genotypes for variants in FANCC.

What This Gene Does
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group C. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
"FA complementation groups|FA core complex"
Locus Type
gene with protein product
Location
9q22.32
Ensembl
ENSG00000158169
Associated Conditions (16)
Fanconi anemia complementation group C
Fanconi anemia
Hereditary cancer-predisposing syndrome
FANCC-related disorder
Ovarian cancer
Malignant tumor of breast
Hereditary cancer
Fanconi anemia complementation group A
Hereditary breast ovarian cancer syndrome
Sarcoma
Gastric cancer
Ovarian serous cystadenocarcinoma
Uterine carcinosarcoma
Familial ovarian cancer
Melanoma
Carcinoma of colon
Key Variants
RS1057516298
Conflicting classifications of pathogenicity
Fanconi anemia complementation group C, Fanconi anemia, Hereditary cancer-predisposing syndrome
Health Risk
RS1057521714
Conflicting classifications of pathogenicity
Fanconi anemia, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group C
Health Risk
RS1057522128
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group C, Hereditary cancer-predisposing syndrome
Health Risk
RS1064793109
Conflicting classifications of pathogenicity
FANCC-related disorder, Hereditary cancer-predisposing syndrome, FANCC-related disorder
Health Risk
RS1064793110
Conflicting classifications of pathogenicity
Fanconi anemia complementation group C, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group C
Health Risk
RS1064793625
Conflicting classifications of pathogenicity
Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group C, Hereditary cancer-predisposing syndrome
Health Risk
RS1064793837
Conflicting classifications of pathogenicity
Fanconi anemia, Hereditary cancer-predisposing syndrome, Fanconi anemia
Health Risk
RS1064794691
Conflicting classifications of pathogenicity
Fanconi anemia, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group C
Health Risk
RS1197938479
Conflicting classifications of pathogenicity
Fanconi anemia, Hereditary cancer-predisposing syndrome, Fanconi anemia
Health Risk
RS1224625808
Conflicting classifications of pathogenicity
Fanconi anemia, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group C
Health Risk
RS1228873579
Conflicting classifications of pathogenicity
Fanconi anemia, Hereditary cancer-predisposing syndrome, Fanconi anemia
Health Risk
RS1228886763
Conflicting classifications of pathogenicity
Fanconi anemia complementation group C, Fanconi anemia, Fanconi anemia complementation group C
Health Risk
All Variants (371)
RSID Category Clinical Significance Conditions
RS1057516917 Health Risk Likely pathogenic Fanconi anemia complementation group C, Fanconi anemia, Fanconi anemia complementation group C
RS1057516963 Health Risk Likely pathogenic Fanconi anemia complementation group C, Fanconi anemia complementation group C
RS1057517125 Health Risk Likely pathogenic Fanconi anemia complementation group C, Fanconi anemia, Hereditary cancer-predisposing syndrome
RS1057517147 Health Risk Likely pathogenic Fanconi anemia complementation group C, Fanconi anemia complementation group C
RS1057517170 Health Risk Likely pathogenic Fanconi anemia complementation group C, Fanconi anemia complementation group C
RS1175257797 Health Risk Likely pathogenic Fanconi anemia, Hereditary cancer-predisposing syndrome, Fanconi anemia
RS1254639941 Health Risk Likely pathogenic Fanconi anemia, Fanconi anemia complementation group C, Fanconi anemia
RS1343170313 Health Risk Likely pathogenic Fanconi anemia, Fanconi anemia
RS1364238660 Health Risk Likely pathogenic Fanconi anemia complementation group C, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group C
RS1407999116 Health Risk Likely pathogenic Hereditary cancer-predisposing syndrome, Fanconi anemia, Fanconi anemia complementation group C
RS145394391 Health Risk Likely pathogenic Fanconi anemia, Fanconi anemia complementation group C, Hereditary cancer-predisposing syndrome
RS1484503633 Health Risk Likely pathogenic Fanconi anemia complementation group C, Fanconi anemia, Hereditary cancer-predisposing syndrome
RS1554827136 Health Risk Likely pathogenic Fanconi anemia complementation group C, Fanconi anemia complementation group C
RS1554827166 Health Risk Likely pathogenic Fanconi anemia complementation group C, Fanconi anemia complementation group C
RS1554829441 Health Risk Likely pathogenic Fanconi anemia, Fanconi anemia complementation group C, Fanconi anemia
RS1554829555 Health Risk Likely pathogenic Fanconi anemia complementation group C, Fanconi anemia complementation group C
RS1554829575 Health Risk Likely pathogenic Fanconi anemia complementation group C, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group C
RS1554830220 Health Risk Likely pathogenic Fanconi anemia complementation group C, Fanconi anemia complementation group C
RS1554830789 Health Risk Likely pathogenic Fanconi anemia complementation group C, Fanconi anemia, Fanconi anemia complementation group C
RS1554833186 Health Risk Likely pathogenic Fanconi anemia, Fanconi anemia complementation group C, Fanconi anemia
RS1554842855 Health Risk Likely pathogenic —
RS1554857855 Health Risk Likely pathogenic —
RS1554858249 Health Risk Likely pathogenic Fanconi anemia complementation group C, Fanconi anemia, Hereditary cancer-predisposing syndrome
RS1564678996 Health Risk Likely pathogenic Ovarian cancer, Ovarian cancer
RS1564719151 Health Risk Likely pathogenic Fanconi anemia complementation group C, Fanconi anemia complementation group C
RS1588070986 Health Risk Likely pathogenic Hereditary cancer-predisposing syndrome, Hereditary cancer-predisposing syndrome
RS1588101086 Health Risk Likely pathogenic Fanconi anemia complementation group C, Fanconi anemia complementation group C
RS1588134180 Health Risk Likely pathogenic Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group C, Hereditary cancer-predisposing syndrome
RS1588134748 Health Risk Likely pathogenic Fanconi anemia, Hereditary cancer-predisposing syndrome, Fanconi anemia
RS1825652774 Health Risk Likely pathogenic Fanconi anemia complementation group C, Fanconi anemia complementation group C
RS1825653450 Health Risk Likely pathogenic Fanconi anemia complementation group C, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group C
RS1825725461 Health Risk Likely pathogenic Fanconi anemia, Fanconi anemia complementation group C, Fanconi anemia
RS1825770738 Health Risk Likely pathogenic Fanconi anemia, Hereditary cancer-predisposing syndrome, Fanconi anemia complementation group C
RS1825770865 Health Risk Likely pathogenic Fanconi anemia complementation group C, Fanconi anemia complementation group C
RS1827526425 Health Risk Likely pathogenic Fanconi anemia complementation group C, Fanconi anemia complementation group C
RS1830059125 Health Risk Likely pathogenic Fanconi anemia complementation group C, Fanconi anemia complementation group C
RS1830581816 Health Risk Likely pathogenic Fanconi anemia, Fanconi anemia complementation group C, Fanconi anemia
RS1830584796 Health Risk Likely pathogenic Fanconi anemia complementation group C, Fanconi anemia complementation group C
RS2071939263 Health Risk Likely pathogenic Fanconi anemia complementation group C, Fanconi anemia complementation group C
RS2072245226 Health Risk Likely pathogenic Fanconi anemia complementation group C, Fanconi anemia complementation group C
RS2072504418 Health Risk Likely pathogenic Fanconi anemia complementation group C, Fanconi anemia complementation group C, Fanconi anemia complementation group C
RS2134456773 Health Risk Likely pathogenic Ovarian cancer, Ovarian cancer
RS2134456820 Health Risk Likely pathogenic Fanconi anemia, Fanconi anemia, Fanconi anemia
RS2135587402 Health Risk Likely pathogenic Fanconi anemia, Fanconi anemia
RS2136090597 Health Risk Likely pathogenic Fanconi anemia, Fanconi anemia
RS2540881892 Health Risk Likely pathogenic Fanconi anemia complementation group C, Fanconi anemia complementation group C
RS2540882312 Health Risk Likely pathogenic —
RS2540882734 Health Risk Likely pathogenic Fanconi anemia complementation group C, Fanconi anemia complementation group C
RS2540883356 Health Risk Likely pathogenic Fanconi anemia complementation group C, Fanconi anemia complementation group C
RS2540884610 Health Risk Likely pathogenic Fanconi anemia complementation group C, Fanconi anemia complementation group C
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