FAM149B1 Chromosome 10

Family with sequence similarity 149 member B1
7 variants 7 Health Risk

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What This Gene Does
Involved in cilium assembly and protein localization to cilium. Predicted to be located in cilium. Implicated in Joubert syndrome. [provided by Alliance of Genome Resources, Jul 2025]
Associated Conditions (3)
Joubert syndrome 36
Joubert syndrome
Clear cell carcinoma of kidney
Key Variants
All Variants (7)
RSID Category Clinical Significance Conditions
RS770670664 Health Risk Conflicting classifications of pathogenicity
RS144804269 Health Risk Likely pathogenic Joubert syndrome 36, Joubert syndrome 36
RS1589150410 Health Risk Likely pathogenic Joubert syndrome 36, Joubert syndrome, Joubert syndrome 36
RS941024653 Health Risk Likely pathogenic Joubert syndrome 36, Joubert syndrome 36
RS1233151424 Health Risk Pathogenic Joubert syndrome 36, Joubert syndrome 36
RS1259897171 Health Risk Pathogenic Joubert syndrome 36, Joubert syndrome 36
RS750681131 Health Risk Pathogenic Joubert syndrome 36, Clear cell carcinoma of kidney, Joubert syndrome 36
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