DPP3 Chromosome 11
Dipeptidyl peptidase 3
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What This Gene Does
This gene encodes a protein that is a member of the M49 family of metallopeptidases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Increased activity of this protein is associated with endometrial and ovarian cancers. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2012]
Gene Info
Gene Group
M49 metallopeptidase family
Locus Type
gene with protein product
Location
11q13.2
Ensembl
ENSG00000254986
All Variants (1)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS34504069 | Health Risk | Conflicting classifications of pathogenicity | — |