DOCK10 Chromosome 2
Dedicator of cytokinesis 10
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What This Gene Does
This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family are guanosine nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions. The encoded protein belongs to the D (or Zizimin) subfamily of DOCK proteins, which also contain an N-terminal pleckstrin homology domain. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Mar 2014]
Gene Info
Gene Group
"Pleckstrin homology domain containing|Armadillo like helical domain containing|DOCK family Rho GEFs|MicroRNA protein coding host genes"
Locus Type
gene with protein product
Location
2q36.2
Ensembl
ENSG00000135905
All Variants (1)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS180691490 | Health Risk | Conflicting classifications of pathogenicity | — |