DNHD1 Chromosome 11
Dynein heavy chain domain 1
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What This Gene Does
Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Involved in sperm flagellum assembly. Located in sperm flagellum. Implicated in spermatogenic failure 65. [provided by Alliance of Genome Resources, Jul 2025]
Associated Conditions (5)
DNHD1-related disorder
Spermatogenic failure 65
Ovarian serous cystadenocarcinoma
Male infertility with spermatogenesis disorder
See cases
Key Variants
RS12574381
Conflicting classifications of pathogenicity
DNHD1-related disorder, Spermatogenic failure 65, DNHD1-related disorder
Health Risk
RS138517528
Conflicting classifications of pathogenicity
DNHD1-related disorder, DNHD1-related disorder
Health Risk
RS142389357
Conflicting classifications of pathogenicity
Health Risk
RS143422606
Conflicting classifications of pathogenicity
DNHD1-related disorder, DNHD1-related disorder
Health Risk
RS149962461
Conflicting classifications of pathogenicity
Health Risk
RS180925806
Conflicting classifications of pathogenicity
Ovarian serous cystadenocarcinoma, Ovarian serous cystadenocarcinoma
Health Risk
RS189772244
Conflicting classifications of pathogenicity
Health Risk
RS375892626
Conflicting classifications of pathogenicity
Health Risk
RS73407163
Conflicting classifications of pathogenicity
DNHD1-related disorder, DNHD1-related disorder
Health Risk
RS750156561
Conflicting classifications of pathogenicity
Male infertility with spermatogenesis disorder, Male infertility with spermatogenesis disorder
Health Risk
RS751352585
Conflicting classifications of pathogenicity
Health Risk
RS759052984
Conflicting classifications of pathogenicity
Male infertility with spermatogenesis disorder, DNHD1-related disorder, Male infertility with spermatogenesis disorder
Health Risk
All Variants (52)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS61729699 | Health Risk | Pathogenic/Likely pathogenic | Spermatogenic failure 65, Spermatogenic failure 65 |
| RS760673520 | Health Risk | Pathogenic/Likely pathogenic | Spermatogenic failure 65, Spermatogenic failure 65 |