DNAJC6 Chromosome 1
DnaJ heat shock protein family (Hsp40) member C6
Upload your DNA to see your personal genotypes for variants in DNAJC6.
What This Gene Does
DNAJC6 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus, a glycine/phenylalanine (G/F)-rich region, and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain (Ohtsuka and Hata, 2000 [PubMed 11147971]).[supplied by OMIM, Mar 2008]
Gene Info
Gene Group
"DNAJ (HSP40) heat shock proteins|C2 tensin-type domain containing"
Locus Type
gene with protein product
Location
1p31.3
Ensembl
ENSG00000116675
Associated Conditions (7)
Juvenile onset Parkinson disease 19A
Inborn genetic diseases
DNAJC6-related disorder
Juvenile-onset diabetes mellitus-central and peripheral neurodegeneration syndrome
Prostate cancer
Parkinson disease 19B
early-onset
Key Variants
RS141779215
Conflicting classifications of pathogenicity
Juvenile onset Parkinson disease 19A, Inborn genetic diseases, Juvenile onset Parkinson disease 19A
Health Risk
RS145329294
Conflicting classifications of pathogenicity
Juvenile onset Parkinson disease 19A, DNAJC6-related disorder, Juvenile onset Parkinson disease 19A
Health Risk
RS376352654
Conflicting classifications of pathogenicity
Juvenile onset Parkinson disease 19A, Juvenile onset Parkinson disease 19A
Health Risk
RS561389842
Conflicting classifications of pathogenicity
Juvenile onset Parkinson disease 19A, Juvenile onset Parkinson disease 19A
Health Risk
RS1219237924
Likely pathogenic
Juvenile onset Parkinson disease 19A, Juvenile onset Parkinson disease 19A
Health Risk
RS2525233935
Likely pathogenic
Juvenile onset Parkinson disease 19A, Juvenile onset Parkinson disease 19A
Health Risk
RS2525354474
Likely pathogenic
Juvenile onset Parkinson disease 19A, Juvenile onset Parkinson disease 19A
Health Risk
RS1645848679
Pathogenic
Juvenile onset Parkinson disease 19A, Juvenile onset Parkinson disease 19A
Health Risk
RS1645867120
Pathogenic
Juvenile onset Parkinson disease 19A, Juvenile onset Parkinson disease 19A
Health Risk
RS2101635447
Pathogenic
Juvenile onset Parkinson disease 19A, Juvenile onset Parkinson disease 19A
Health Risk
RS398122404
Pathogenic
Juvenile onset Parkinson disease 19A, Juvenile-onset diabetes mellitus-central and peripheral neurodegeneration syndrome, Juvenile onset Parkinson disease 19A
Health Risk
RS398122405
Pathogenic
Juvenile onset Parkinson disease 19A, Juvenile onset Parkinson disease 19A
Health Risk
All Variants (15)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS141779215 | Health Risk | Conflicting classifications of pathogenicity | Juvenile onset Parkinson disease 19A, Inborn genetic diseases, Juvenile onset Parkinson disease 19A |
| RS145329294 | Health Risk | Conflicting classifications of pathogenicity | Juvenile onset Parkinson disease 19A, DNAJC6-related disorder, Juvenile onset Parkinson disease 19A |
| RS376352654 | Health Risk | Conflicting classifications of pathogenicity | Juvenile onset Parkinson disease 19A, Juvenile onset Parkinson disease 19A |
| RS561389842 | Health Risk | Conflicting classifications of pathogenicity | Juvenile onset Parkinson disease 19A, Juvenile onset Parkinson disease 19A |
| RS1219237924 | Health Risk | Likely pathogenic | Juvenile onset Parkinson disease 19A, Juvenile onset Parkinson disease 19A |
| RS2525233935 | Health Risk | Likely pathogenic | Juvenile onset Parkinson disease 19A, Juvenile onset Parkinson disease 19A |
| RS2525354474 | Health Risk | Likely pathogenic | Juvenile onset Parkinson disease 19A, Juvenile onset Parkinson disease 19A |
| RS1645848679 | Health Risk | Pathogenic | Juvenile onset Parkinson disease 19A, Juvenile onset Parkinson disease 19A |
| RS1645867120 | Health Risk | Pathogenic | Juvenile onset Parkinson disease 19A, Juvenile onset Parkinson disease 19A |
| RS2101635447 | Health Risk | Pathogenic | Juvenile onset Parkinson disease 19A, Juvenile onset Parkinson disease 19A |
| RS398122404 | Health Risk | Pathogenic | Juvenile onset Parkinson disease 19A, Juvenile-onset diabetes mellitus-central and peripheral neurodegeneration syndrome, Juvenile onset Parkinson disease 19A |
| RS398122405 | Health Risk | Pathogenic | Juvenile onset Parkinson disease 19A, Juvenile onset Parkinson disease 19A |
| RS864622011 | Health Risk | Pathogenic | Prostate cancer, Juvenile onset Parkinson disease 19A, Prostate cancer |
| RS879255630 | Health Risk | Pathogenic | Parkinson disease 19B, early-onset, Juvenile onset Parkinson disease 19A |
| RS886039854 | Health Risk | Pathogenic | Juvenile onset Parkinson disease 19A, Juvenile onset Parkinson disease 19A |