DNAH10 Chromosome 12
Dynein axonemal heavy chain 10
Upload your DNA to see your personal genotypes for variants in DNAH10.
What This Gene Does
Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. The axonemal dyneins, found in cilia and flagella, are components of the outer and inner dynein arms attached to the peripheral microtubule doublets. DNAH10 is an inner arm dynein heavy chain (Maiti et al., 2000 [PubMed 11175280]).[supplied by OMIM, Mar 2008]
Gene Info
Gene Group
Dyneins, axonemal inner arm I1/f complex subunits
Locus Type
gene with protein product
Location
12q24.31
Ensembl
ENSG00000197653
Associated Conditions (2)
DNAH10-related disorder
Spermatogenic failure 56
Key Variants
RS118146260
Conflicting classifications of pathogenicity
Health Risk
RS138151312
Conflicting classifications of pathogenicity
Health Risk
RS144421774
Conflicting classifications of pathogenicity
DNAH10-related disorder, DNAH10-related disorder
Health Risk
RS145614363
Conflicting classifications of pathogenicity
Health Risk
RS552141374
Conflicting classifications of pathogenicity
Health Risk
RS73221409
Conflicting classifications of pathogenicity
DNAH10-related disorder, DNAH10-related disorder
Health Risk
RS759073156
Likely pathogenic
Spermatogenic failure 56, Spermatogenic failure 56
Health Risk
RS2136959456
Pathogenic
Spermatogenic failure 56, Spermatogenic failure 56
Health Risk
RS2137700684
Pathogenic
Spermatogenic failure 56, Spermatogenic failure 56
Health Risk
All Variants (9)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS118146260 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS138151312 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS144421774 | Health Risk | Conflicting classifications of pathogenicity | DNAH10-related disorder, DNAH10-related disorder |
| RS145614363 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS552141374 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS73221409 | Health Risk | Conflicting classifications of pathogenicity | DNAH10-related disorder, DNAH10-related disorder |
| RS759073156 | Health Risk | Likely pathogenic | Spermatogenic failure 56, Spermatogenic failure 56 |
| RS2136959456 | Health Risk | Pathogenic | Spermatogenic failure 56, Spermatogenic failure 56 |
| RS2137700684 | Health Risk | Pathogenic | Spermatogenic failure 56, Spermatogenic failure 56 |