DAAM2 Chromosome 6
Dishevelled associated activator of morphogenesis 2
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What This Gene Does
Predicted to enable actin binding activity and small GTPase binding activity. Involved in several processes, including podocyte cell migration; regulation of actin filament polymerization; and regulation of filopodium assembly. Located in extracellular exosome. Implicated in familial nephrotic syndrome. [provided by Alliance of Genome Resources, Jul 2025]
Gene Info
Gene Group
"Armadillo like helical domain containing|Formins"
Locus Type
gene with protein product
Location
6p21.2
Ensembl
ENSG00000146122
Associated Conditions (3)
Nephrotic syndrome
type 24
DAAM2-related disorder
Key Variants
RS111950018
Conflicting classifications of pathogenicity
Nephrotic syndrome, type 24, DAAM2-related disorder
Health Risk
RS1391253919
Pathogenic
Nephrotic syndrome, type 24, Nephrotic syndrome
Health Risk
RS1764951663
Pathogenic
Nephrotic syndrome, type 24, Nephrotic syndrome
Health Risk
RS200668867
Pathogenic
Nephrotic syndrome, type 24, Nephrotic syndrome
Health Risk
All Variants (4)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS111950018 | Health Risk | Conflicting classifications of pathogenicity | Nephrotic syndrome, type 24, DAAM2-related disorder |
| RS1391253919 | Health Risk | Pathogenic | Nephrotic syndrome, type 24, Nephrotic syndrome |
| RS1764951663 | Health Risk | Pathogenic | Nephrotic syndrome, type 24, Nephrotic syndrome |
| RS200668867 | Health Risk | Pathogenic | Nephrotic syndrome, type 24, Nephrotic syndrome |