CRY1 Chromosome 12
Cryptochrome circadian regulator 1
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What This Gene Does
This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness. [provided by RefSeq, Jan 2014]
Gene Info
Gene Group
Flavoproteins
Locus Type
gene with protein product
Location
12q23.3
Ensembl
ENSG00000008405
Associated Conditions (21)
Sleep-wake schedule disorder
delayed phase type
Attention deficit hyperactivity disorder
Delayed sleep phase syndrome
susceptibility to
Uterine corpus endometrial carcinoma
Clear cell carcinoma of kidney
Colon adenocarcinoma
Colorectal cancer
Gastric cancer
Nonpapillary renal cell carcinoma
Cervical cancer
Sarcoma
Ovarian serous cystadenocarcinoma
Hepatocellular carcinoma
Lung cancer
Familial cancer of breast
Thymoma
Melanoma
Acute myeloid leukemia
+1 more conditions
Key Variants
All Variants (2)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS780614131 | Health Risk | association | Sleep-wake schedule disorder, delayed phase type, Attention deficit hyperactivity disorder |
| RS184039278 | Health Risk | association; risk factor | Delayed sleep phase syndrome, susceptibility to, Attention deficit hyperactivity disorder |