CRKL Chromosome 22
CRK like proto-oncogene, adaptor protein
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What This Gene Does
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]
Gene Info
Gene Group
SH2 domain containing
Locus Type
gene with protein product
Location
22q11.21
Ensembl
ENSG00000099942
All Variants (1)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS769606385 | Health Risk | Conflicting classifications of pathogenicity | — |