COMT Chromosome 22

Catechol-O-methyltransferase

162 variants 161 Drug Response 1 Health Risk

Upload your DNA to see your personal genotypes for variants in COMT.

What This Gene Does

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]

Gene Info

Gene Group

"MicroRNA protein coding host genes|7BS small molecule methyltransferases|Small molecule methyltransferases"

Locus Type

gene with protein product

Location

22q11.21

Ensembl

ENSG00000093010

Associated Conditions (2)

Tramadol response

Bardet-Biedl syndrome

Key Variants

RS1040891994

drug response

Tramadol response, Tramadol response

Drug Response

RS1042965728

drug response

Tramadol response, Tramadol response

Drug Response

RS1043850772

drug response

Tramadol response, Tramadol response

Drug Response

RS11569716

drug response

Tramadol response, Tramadol response

Drug Response

RS1160435070

drug response

Tramadol response, Tramadol response

Drug Response

RS1191232468

drug response

Tramadol response, Tramadol response

Drug Response

RS1194870751

drug response

Tramadol response, Tramadol response

Drug Response

RS1213698422

drug response

Tramadol response, Tramadol response

Drug Response

RS1223964672

drug response

Tramadol response, Tramadol response

Drug Response

RS1243347237

drug response

Tramadol response, Tramadol response

Drug Response

RS1266810183

drug response

Tramadol response, Tramadol response

Drug Response

RS1281747131

drug response

Tramadol response, Tramadol response

Drug Response

All Variants (162)

RSID	Category	Clinical Significance	Conditions
RS1040891994	Drug Response	drug response	Tramadol response, Tramadol response
RS1042965728	Drug Response	drug response	Tramadol response, Tramadol response
RS1043850772	Drug Response	drug response	Tramadol response, Tramadol response
RS11569716	Drug Response	drug response	Tramadol response, Tramadol response
RS1160435070	Drug Response	drug response	Tramadol response, Tramadol response
RS1191232468	Drug Response	drug response	Tramadol response, Tramadol response
RS1194870751	Drug Response	drug response	Tramadol response, Tramadol response
RS1213698422	Drug Response	drug response	Tramadol response, Tramadol response
RS1223964672	Drug Response	drug response	Tramadol response, Tramadol response
RS1243347237	Drug Response	drug response	Tramadol response, Tramadol response
RS1266810183	Drug Response	drug response	Tramadol response, Tramadol response
RS1281747131	Drug Response	drug response	Tramadol response, Tramadol response
RS1299165007	Drug Response	drug response	Tramadol response, Tramadol response
RS1303813995	Drug Response	drug response	Tramadol response, Tramadol response
RS1306169298	Drug Response	drug response	Tramadol response, Tramadol response
RS1337529868	Drug Response	drug response	Tramadol response, Tramadol response
RS1374067391	Drug Response	drug response	Tramadol response, Tramadol response
RS1380337718	Drug Response	drug response	Tramadol response, Tramadol response
RS1383104098	Drug Response	drug response	Tramadol response, Tramadol response
RS138327309	Drug Response	drug response	Tramadol response, Tramadol response
RS1388042103	Drug Response	drug response	Tramadol response, Tramadol response
RS1393666377	Drug Response	drug response	Tramadol response, Tramadol response
RS1406904538	Drug Response	drug response	Tramadol response, Tramadol response
RS1407237513	Drug Response	drug response	Tramadol response, Tramadol response
RS1426955262	Drug Response	drug response	Tramadol response, Tramadol response
RS1428959883	Drug Response	drug response	Tramadol response, Tramadol response
RS144623972	Drug Response	drug response	Tramadol response, Tramadol response
RS1468243199	Drug Response	drug response	Tramadol response, Tramadol response
RS147863086	Drug Response	drug response	Tramadol response, Tramadol response
RS1601500636	Drug Response	drug response	Tramadol response, Tramadol response
RS1601501100	Drug Response	drug response	Tramadol response, Tramadol response
RS1601501107	Drug Response	drug response	Tramadol response, Tramadol response
RS1601501281	Drug Response	drug response	Tramadol response, Tramadol response
RS1601501698	Drug Response	drug response	Tramadol response, Tramadol response
RS1601511512	Drug Response	drug response	Tramadol response, Tramadol response
RS1601511531	Drug Response	drug response	Tramadol response, Tramadol response
RS1601511537	Drug Response	drug response	Tramadol response, Tramadol response
RS1601511546	Drug Response	drug response	Tramadol response, Tramadol response
RS1601512573	Drug Response	drug response	Tramadol response, Tramadol response
RS1601512579	Drug Response	drug response	Tramadol response, Tramadol response
RS1601512585	Drug Response	drug response	Tramadol response, Tramadol response
RS1601512593	Drug Response	drug response	Tramadol response, Tramadol response
RS1601512599	Drug Response	drug response	Tramadol response, Tramadol response
RS1601512609	Drug Response	drug response	Tramadol response, Tramadol response
RS1601512631	Drug Response	drug response	Tramadol response, Tramadol response
RS1601512664	Drug Response	drug response	Tramadol response, Tramadol response
RS1601512790	Drug Response	drug response	Tramadol response, Tramadol response
RS1601512807	Drug Response	drug response	Tramadol response, Tramadol response
RS1601512964	Drug Response	drug response	Tramadol response, Tramadol response
RS1601525062	Drug Response	drug response	Tramadol response, Tramadol response

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