COG5 Chromosome 7
Component of oligomeric golgi complex 5
Upload your DNA to see your personal genotypes for variants in COG5.
What This Gene Does
The protein encoded by this gene is one of eight proteins (Cog1-8) which form a Golgi-localized complex (COG) required for normal Golgi morphology and function. The encoded protein is organized with conserved oligomeric Golgi complex components 6, 7 and 8 into a sub-complex referred to as lobe B. Alternative splicing results in multiple transcript variants. Mutations in this gene result in congenital disorder of glycosylation type 2I.[provided by RefSeq, Jan 2011]
Gene Info
Gene Group
Components of oligomeric golgi complex
Locus Type
gene with protein product
Location
7q22.3
Ensembl
ENSG00000164597
Associated Conditions (5)
COG5-congenital disorder of glycosylation
Inborn genetic diseases
COG5-related disorder
Uterine corpus endometrial carcinoma
Sarcoma
Key Variants
RS1033213070
Conflicting classifications of pathogenicity
COG5-congenital disorder of glycosylation, Inborn genetic diseases, COG5-congenital disorder of glycosylation
Health Risk
RS1049832940
Conflicting classifications of pathogenicity
COG5-congenital disorder of glycosylation, COG5-congenital disorder of glycosylation
Health Risk
RS113660545
Conflicting classifications of pathogenicity
COG5-congenital disorder of glycosylation, COG5-congenital disorder of glycosylation
Health Risk
RS138518242
Conflicting classifications of pathogenicity
COG5-congenital disorder of glycosylation, COG5-congenital disorder of glycosylation
Health Risk
RS139763861
Conflicting classifications of pathogenicity
COG5-congenital disorder of glycosylation, Inborn genetic diseases, COG5-related disorder
Health Risk
RS141942249
Conflicting classifications of pathogenicity
COG5-congenital disorder of glycosylation, Inborn genetic diseases, COG5-congenital disorder of glycosylation
Health Risk
RS142276972
Conflicting classifications of pathogenicity
COG5-congenital disorder of glycosylation, Inborn genetic diseases, COG5-related disorder
Health Risk
RS142433421
Conflicting classifications of pathogenicity
COG5-congenital disorder of glycosylation, COG5-related disorder, COG5-congenital disorder of glycosylation
Health Risk
RS142970891
Conflicting classifications of pathogenicity
COG5-congenital disorder of glycosylation, COG5-related disorder, COG5-congenital disorder of glycosylation
Health Risk
RS143773937
Conflicting classifications of pathogenicity
COG5-congenital disorder of glycosylation, Inborn genetic diseases, COG5-related disorder
Health Risk
RS145128460
Conflicting classifications of pathogenicity
COG5-congenital disorder of glycosylation, COG5-related disorder, COG5-congenital disorder of glycosylation
Health Risk
RS145648013
Conflicting classifications of pathogenicity
COG5-congenital disorder of glycosylation, COG5-congenital disorder of glycosylation
Health Risk
All Variants (95)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS1033213070 | Health Risk | Conflicting classifications of pathogenicity | COG5-congenital disorder of glycosylation, Inborn genetic diseases, COG5-congenital disorder of glycosylation |
| RS1049832940 | Health Risk | Conflicting classifications of pathogenicity | COG5-congenital disorder of glycosylation, COG5-congenital disorder of glycosylation |
| RS113660545 | Health Risk | Conflicting classifications of pathogenicity | COG5-congenital disorder of glycosylation, COG5-congenital disorder of glycosylation |
| RS138518242 | Health Risk | Conflicting classifications of pathogenicity | COG5-congenital disorder of glycosylation, COG5-congenital disorder of glycosylation |
| RS139763861 | Health Risk | Conflicting classifications of pathogenicity | COG5-congenital disorder of glycosylation, Inborn genetic diseases, COG5-related disorder |
| RS141942249 | Health Risk | Conflicting classifications of pathogenicity | COG5-congenital disorder of glycosylation, Inborn genetic diseases, COG5-congenital disorder of glycosylation |
| RS142276972 | Health Risk | Conflicting classifications of pathogenicity | COG5-congenital disorder of glycosylation, Inborn genetic diseases, COG5-related disorder |
| RS142433421 | Health Risk | Conflicting classifications of pathogenicity | COG5-congenital disorder of glycosylation, COG5-related disorder, COG5-congenital disorder of glycosylation |
| RS142970891 | Health Risk | Conflicting classifications of pathogenicity | COG5-congenital disorder of glycosylation, COG5-related disorder, COG5-congenital disorder of glycosylation |
| RS143773937 | Health Risk | Conflicting classifications of pathogenicity | COG5-congenital disorder of glycosylation, Inborn genetic diseases, COG5-related disorder |
| RS145128460 | Health Risk | Conflicting classifications of pathogenicity | COG5-congenital disorder of glycosylation, COG5-related disorder, COG5-congenital disorder of glycosylation |
| RS145648013 | Health Risk | Conflicting classifications of pathogenicity | COG5-congenital disorder of glycosylation, COG5-congenital disorder of glycosylation |
| RS148020994 | Health Risk | Conflicting classifications of pathogenicity | COG5-congenital disorder of glycosylation, Uterine corpus endometrial carcinoma, COG5-congenital disorder of glycosylation |
| RS149574256 | Health Risk | Conflicting classifications of pathogenicity | COG5-congenital disorder of glycosylation, Sarcoma, COG5-congenital disorder of glycosylation |
| RS150351852 | Health Risk | Conflicting classifications of pathogenicity | COG5-congenital disorder of glycosylation, COG5-congenital disorder of glycosylation |
| RS189560910 | Health Risk | Conflicting classifications of pathogenicity | COG5-congenital disorder of glycosylation, COG5-congenital disorder of glycosylation |
| RS193127052 | Health Risk | Conflicting classifications of pathogenicity | COG5-congenital disorder of glycosylation, COG5-congenital disorder of glycosylation |
| RS199592702 | Health Risk | Conflicting classifications of pathogenicity | COG5-congenital disorder of glycosylation, COG5-congenital disorder of glycosylation |
| RS200107630 | Health Risk | Conflicting classifications of pathogenicity | COG5-congenital disorder of glycosylation, COG5-congenital disorder of glycosylation |
| RS202123650 | Health Risk | Conflicting classifications of pathogenicity | COG5-congenital disorder of glycosylation, COG5-congenital disorder of glycosylation |
| RS35258567 | Health Risk | Conflicting classifications of pathogenicity | COG5-congenital disorder of glycosylation, COG5-related disorder, Inborn genetic diseases |
| RS35393416 | Health Risk | Conflicting classifications of pathogenicity | COG5-congenital disorder of glycosylation, COG5-related disorder, COG5-congenital disorder of glycosylation |
| RS372226278 | Health Risk | Conflicting classifications of pathogenicity | COG5-congenital disorder of glycosylation, COG5-congenital disorder of glycosylation |
| RS373280339 | Health Risk | Conflicting classifications of pathogenicity | COG5-congenital disorder of glycosylation, COG5-congenital disorder of glycosylation |
| RS374007477 | Health Risk | Conflicting classifications of pathogenicity | COG5-congenital disorder of glycosylation, COG5-congenital disorder of glycosylation |
| RS376958885 | Health Risk | Conflicting classifications of pathogenicity | COG5-congenital disorder of glycosylation, COG5-congenital disorder of glycosylation |
| RS41276187 | Health Risk | Conflicting classifications of pathogenicity | COG5-congenital disorder of glycosylation, COG5-congenital disorder of glycosylation |
| RS549788738 | Health Risk | Conflicting classifications of pathogenicity | COG5-congenital disorder of glycosylation, COG5-congenital disorder of glycosylation |
| RS555908807 | Health Risk | Conflicting classifications of pathogenicity | COG5-congenital disorder of glycosylation, COG5-related disorder, COG5-congenital disorder of glycosylation |
| RS565990382 | Health Risk | Conflicting classifications of pathogenicity | COG5-congenital disorder of glycosylation, COG5-congenital disorder of glycosylation |
| RS746107488 | Health Risk | Conflicting classifications of pathogenicity | COG5-congenital disorder of glycosylation, COG5-congenital disorder of glycosylation |
| RS757452204 | Health Risk | Conflicting classifications of pathogenicity | COG5-congenital disorder of glycosylation, COG5-congenital disorder of glycosylation |
| RS763696416 | Health Risk | Conflicting classifications of pathogenicity | COG5-congenital disorder of glycosylation, COG5-congenital disorder of glycosylation |
| RS764180413 | Health Risk | Conflicting classifications of pathogenicity | COG5-congenital disorder of glycosylation, COG5-congenital disorder of glycosylation |
| RS769195866 | Health Risk | Conflicting classifications of pathogenicity | COG5-congenital disorder of glycosylation, COG5-congenital disorder of glycosylation |
| RS774900756 | Health Risk | Conflicting classifications of pathogenicity | COG5-congenital disorder of glycosylation, COG5-congenital disorder of glycosylation |
| RS975245291 | Health Risk | Conflicting classifications of pathogenicity | COG5-congenital disorder of glycosylation, Inborn genetic diseases, COG5-congenital disorder of glycosylation |
| RS1135401817 | Health Risk | Likely pathogenic | COG5-congenital disorder of glycosylation, COG5-congenital disorder of glycosylation |
| RS1186590801 | Health Risk | Likely pathogenic | COG5-congenital disorder of glycosylation, COG5-congenital disorder of glycosylation |
| RS1237315874 | Health Risk | Likely pathogenic | COG5-congenital disorder of glycosylation, COG5-congenital disorder of glycosylation |
| RS1465217212 | Health Risk | Likely pathogenic | COG5-congenital disorder of glycosylation, COG5-congenital disorder of glycosylation |
| RS1584547374 | Health Risk | Likely pathogenic | COG5-congenital disorder of glycosylation, COG5-congenital disorder of glycosylation |
| RS1584977236 | Health Risk | Likely pathogenic | COG5-congenital disorder of glycosylation, COG5-congenital disorder of glycosylation |
| RS1792377306 | Health Risk | Likely pathogenic | COG5-congenital disorder of glycosylation, COG5-congenital disorder of glycosylation |
| RS1800848418 | Health Risk | Likely pathogenic | COG5-congenital disorder of glycosylation, COG5-congenital disorder of glycosylation |
| RS1800848531 | Health Risk | Likely pathogenic | COG5-congenital disorder of glycosylation, COG5-congenital disorder of glycosylation |
| RS2116623273 | Health Risk | Likely pathogenic | COG5-congenital disorder of glycosylation, COG5-congenital disorder of glycosylation |
| RS2129184409 | Health Risk | Likely pathogenic | COG5-congenital disorder of glycosylation, COG5-congenital disorder of glycosylation |
| RS2535641517 | Health Risk | Likely pathogenic | — |
| RS2536744098 | Health Risk | Likely pathogenic | COG5-congenital disorder of glycosylation, COG5-congenital disorder of glycosylation |