CHRNA5 Chromosome 15
Cholinergic receptor nicotinic alpha 5 subunit
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What This Gene Does
The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2).[provided by RefSeq, Jun 2010]
Gene Info
Gene Group
Cholinergic receptors nicotinic subunits
Locus Type
gene with protein product
Location
15q25.1
Ensembl
ENSG00000169684
Associated Conditions (4)
Lung cancer susceptibility 2
SMOKING AS A QUANTITATIVE TRAIT LOCUS 3
nicotine response - Toxicity
Susceptibility to severe coronavirus disease (COVID-19) due to high levels of fibrinogen and C-reactive protein
All Variants (1)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS16969968 | Drug Response | drug response | Lung cancer susceptibility 2, SMOKING AS A QUANTITATIVE TRAIT LOCUS 3, nicotine response - Toxicity |