CFAP91 Chromosome 3

Cilia and flagella associated protein 91

2 variants 2 Health Risk

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What This Gene Does

Involved in axonemal central apparatus assembly and spermatogenesis. Predicted to be located in motile cilium and radial spoke stalk. Implicated in spermatogenic failure 51. [provided by Alliance of Genome Resources, Jul 2025]

Associated Conditions (2)

Spermatogenic failure 51

Male infertility with teratozoospermia due to single gene mutation

Key Variants

RS757703206

Likely pathogenic

Spermatogenic failure 51, Spermatogenic failure 51

Health Risk

RS147597066

Pathogenic

Male infertility with teratozoospermia due to single gene mutation, Spermatogenic failure 51, Male infertility with teratozoospermia due to single gene mutation

Health Risk

All Variants (2)

RSID	Category	Clinical Significance	Conditions
RS757703206	Health Risk	Likely pathogenic	Spermatogenic failure 51, Spermatogenic failure 51
RS147597066	Health Risk	Pathogenic	Male infertility with teratozoospermia due to single gene mutation, Spermatogenic failure 51, Male infertility with teratozoospermia due to single gene mutation