CELF2 Chromosome 10

CUGBP Elav-like family member 2
8 variants 8 Health Risk

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What This Gene Does
Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
RNA binding motif containing
Locus Type
gene with protein product
Location
10p14
Ensembl
ENSG00000048740
Associated Conditions (3)
CELF2-related disorder
Developmental and epileptic encephalopathy 97
Neurodevelopmental disorder
Key Variants
All Variants (8)
RSID Category Clinical Significance Conditions
RS201674366 Health Risk Likely pathogenic CELF2-related disorder, CELF2-related disorder
RS2132555667 Health Risk Pathogenic Developmental and epileptic encephalopathy 97, Developmental and epileptic encephalopathy 97
RS2132785456 Health Risk Pathogenic Developmental and epileptic encephalopathy 97, Developmental and epileptic encephalopathy 97
RS2132786780 Health Risk Pathogenic Developmental and epileptic encephalopathy 97, Developmental and epileptic encephalopathy 97
RS2132786873 Health Risk Pathogenic Developmental and epileptic encephalopathy 97, Developmental and epileptic encephalopathy 97
RS764892258 Health Risk Pathogenic
RS2132785331 Health Risk Pathogenic/Likely pathogenic Developmental and epileptic encephalopathy 97, Developmental and epileptic encephalopathy 97
RS2138616482 Health Risk Pathogenic/Likely pathogenic Developmental and epileptic encephalopathy 97, Neurodevelopmental disorder, Developmental and epileptic encephalopathy 97
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