CDK12 Chromosome 17
Cyclin dependent kinase 12
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What This Gene Does
Enables RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin binding activity. Involved in several processes, including positive regulation of transcription elongation by RNA polymerase II; protein autophosphorylation; and regulation of MAP kinase activity. Located in nuclear speck. Part of cyclin K-CDK12 complex. Biomarker of gastric adenocarcinoma; hepatocellular carcinoma; and stomach cancer. [provided by Alliance of Genome Resources, Apr 2025]
Gene Info
Gene Group
Cyclin dependent kinases
Locus Type
gene with protein product
Location
17q12
Ensembl
ENSG00000167258
Associated Conditions (2)
Hereditary cancer
Lung adenocarcinoma
Key Variants
All Variants (2)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS767287779 | Health Risk | Conflicting classifications of pathogenicity | Hereditary cancer, Hereditary cancer |
| RS1131692238 | Health Risk | Likely pathogenic | Lung adenocarcinoma, Lung adenocarcinoma |