CDC6 Chromosome 17
Cell division cycle 6
Upload your DNA to see your personal genotypes for variants in CDC6.
What This Gene Does
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008]
Associated Conditions (2)
CDC6-related disorder
Meier-Gorlin syndrome 5
Key Variants
RS147186134
Conflicting classifications of pathogenicity
CDC6-related disorder, CDC6-related disorder
Health Risk
RS148004022
Conflicting classifications of pathogenicity
Health Risk
RS181925915
Conflicting classifications of pathogenicity
Meier-Gorlin syndrome 5, CDC6-related disorder, Meier-Gorlin syndrome 5
Health Risk
RS182086857
Conflicting classifications of pathogenicity
Meier-Gorlin syndrome 5, Meier-Gorlin syndrome 5
Health Risk
RS193186571
Conflicting classifications of pathogenicity
Meier-Gorlin syndrome 5, Meier-Gorlin syndrome 5
Health Risk
RS200407669
Conflicting classifications of pathogenicity
Meier-Gorlin syndrome 5, Meier-Gorlin syndrome 5
Health Risk
RS200468440
Conflicting classifications of pathogenicity
Health Risk
RS2032758309
Conflicting classifications of pathogenicity
Health Risk
RS4135010
Conflicting classifications of pathogenicity
Meier-Gorlin syndrome 5, Meier-Gorlin syndrome 5
Health Risk
RS563505524
Conflicting classifications of pathogenicity
Meier-Gorlin syndrome 5, Meier-Gorlin syndrome 5
Health Risk
All Variants (10)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS147186134 | Health Risk | Conflicting classifications of pathogenicity | CDC6-related disorder, CDC6-related disorder |
| RS148004022 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS181925915 | Health Risk | Conflicting classifications of pathogenicity | Meier-Gorlin syndrome 5, CDC6-related disorder, Meier-Gorlin syndrome 5 |
| RS182086857 | Health Risk | Conflicting classifications of pathogenicity | Meier-Gorlin syndrome 5, Meier-Gorlin syndrome 5 |
| RS193186571 | Health Risk | Conflicting classifications of pathogenicity | Meier-Gorlin syndrome 5, Meier-Gorlin syndrome 5 |
| RS200407669 | Health Risk | Conflicting classifications of pathogenicity | Meier-Gorlin syndrome 5, Meier-Gorlin syndrome 5 |
| RS200468440 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS2032758309 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS4135010 | Health Risk | Conflicting classifications of pathogenicity | Meier-Gorlin syndrome 5, Meier-Gorlin syndrome 5 |
| RS563505524 | Health Risk | Conflicting classifications of pathogenicity | Meier-Gorlin syndrome 5, Meier-Gorlin syndrome 5 |