CDC25A Chromosome 3

Cell division cycle 25A

1 variant 1 Health Risk

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What This Gene Does

CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Info

Gene Group

Class III Cys-based CDC25 phosphatases

Locus Type

gene with protein product

Location

3p21.31

Ensembl

ENSG00000164045

Associated Conditions (1)

Autosomal dominant polycystic liver disease

Key Variants

RS3731499

Likely pathogenic

Autosomal dominant polycystic liver disease, Autosomal dominant polycystic liver disease

Health Risk

All Variants (1)

RSID	Category	Clinical Significance	Conditions
RS3731499	Health Risk	Likely pathogenic	Autosomal dominant polycystic liver disease, Autosomal dominant polycystic liver disease