CDC14A Chromosome 1
Cell division cycle 14A
Upload your DNA to see your personal genotypes for variants in CDC14A.
What This Gene Does
The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Gene Info
Gene Group
CDC14 phosphatases
Locus Type
gene with protein product
Location
1p21.2
Ensembl
ENSG00000079335
Associated Conditions (9)
CDC14A-related disorder
Familial cancer of breast
Inborn genetic diseases
Lung cancer
Autosomal recessive nonsyndromic hearing loss 32
Monogenic hearing loss
Rare genetic deafness
Sensorineural hearing loss disorder
Ear malformation
Key Variants
RS112231082
Conflicting classifications of pathogenicity
CDC14A-related disorder, Familial cancer of breast, Inborn genetic diseases
Health Risk
RS1309255666
Conflicting classifications of pathogenicity
Health Risk
RS140021980
Conflicting classifications of pathogenicity
CDC14A-related disorder, Inborn genetic diseases, CDC14A-related disorder
Health Risk
RS140623300
Conflicting classifications of pathogenicity
Health Risk
RS143117380
Conflicting classifications of pathogenicity
Inborn genetic diseases, Inborn genetic diseases
Health Risk
RS375381230
Conflicting classifications of pathogenicity
Autosomal recessive nonsyndromic hearing loss 32, Autosomal recessive nonsyndromic hearing loss 32
Health Risk
RS571098288
Conflicting classifications of pathogenicity
Health Risk
RS748922639
Conflicting classifications of pathogenicity
Inborn genetic diseases, Inborn genetic diseases
Health Risk
RS771516972
Conflicting classifications of pathogenicity
Health Risk
RS1339709390
Likely pathogenic
Autosomal recessive nonsyndromic hearing loss 32, Autosomal recessive nonsyndromic hearing loss 32
Health Risk
RS1553191001
Likely pathogenic
Autosomal recessive nonsyndromic hearing loss 32, Monogenic hearing loss, Autosomal recessive nonsyndromic hearing loss 32
Health Risk
RS2100872719
Likely pathogenic
Autosomal recessive nonsyndromic hearing loss 32, Autosomal recessive nonsyndromic hearing loss 32
Health Risk
All Variants (26)
| RSID | Category | Clinical Significance | Conditions |
|---|---|---|---|
| RS112231082 | Health Risk | Conflicting classifications of pathogenicity | CDC14A-related disorder, Familial cancer of breast, Inborn genetic diseases |
| RS1309255666 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS140021980 | Health Risk | Conflicting classifications of pathogenicity | CDC14A-related disorder, Inborn genetic diseases, CDC14A-related disorder |
| RS140623300 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS143117380 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Inborn genetic diseases |
| RS375381230 | Health Risk | Conflicting classifications of pathogenicity | Autosomal recessive nonsyndromic hearing loss 32, Autosomal recessive nonsyndromic hearing loss 32 |
| RS571098288 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS748922639 | Health Risk | Conflicting classifications of pathogenicity | Inborn genetic diseases, Inborn genetic diseases |
| RS771516972 | Health Risk | Conflicting classifications of pathogenicity | — |
| RS1339709390 | Health Risk | Likely pathogenic | Autosomal recessive nonsyndromic hearing loss 32, Autosomal recessive nonsyndromic hearing loss 32 |
| RS1553191001 | Health Risk | Likely pathogenic | Autosomal recessive nonsyndromic hearing loss 32, Monogenic hearing loss, Autosomal recessive nonsyndromic hearing loss 32 |
| RS2100872719 | Health Risk | Likely pathogenic | Autosomal recessive nonsyndromic hearing loss 32, Autosomal recessive nonsyndromic hearing loss 32 |
| RS2524299734 | Health Risk | Likely pathogenic | — |
| RS765155697 | Health Risk | Likely pathogenic | Rare genetic deafness, Rare genetic deafness |
| RS1571346132 | Health Risk | Pathogenic | Sensorineural hearing loss disorder, Sensorineural hearing loss disorder |
| RS2524330554 | Health Risk | Pathogenic | — |
| RS759201338 | Health Risk | Pathogenic | Autosomal recessive nonsyndromic hearing loss 32, Autosomal recessive nonsyndromic hearing loss 32 |
| RS770995792 | Health Risk | Pathogenic | — |
| RS771622183 | Health Risk | Pathogenic | Autosomal recessive nonsyndromic hearing loss 32, Autosomal recessive nonsyndromic hearing loss 32 |
| RS772540473 | Health Risk | Pathogenic | — |
| RS773911500 | Health Risk | Pathogenic | — |
| RS777112652 | Health Risk | Pathogenic | Autosomal recessive nonsyndromic hearing loss 32, Autosomal recessive nonsyndromic hearing loss 32 |
| RS148737918 | Health Risk | Pathogenic/Likely pathogenic | Autosomal recessive nonsyndromic hearing loss 32, Autosomal recessive nonsyndromic hearing loss 32 |
| RS369245990 | Health Risk | Pathogenic/Likely pathogenic | Autosomal recessive nonsyndromic hearing loss 32, Autosomal recessive nonsyndromic hearing loss 32 |
| RS549556142 | Health Risk | Pathogenic/Likely pathogenic | Autosomal recessive nonsyndromic hearing loss 32, Ear malformation, Autosomal recessive nonsyndromic hearing loss 32 |
| RS876661408 | Health Risk | Pathogenic/Likely pathogenic | Autosomal recessive nonsyndromic hearing loss 32, Ear malformation, CDC14A-related disorder |